Optipranolol

Open Angle Glaucoma, Ocular Hypertension

Treatment

4 FDA approvals

18 Active Studies for Optipranolol

What is Optipranolol

Metipranolol

The Generic name of this drug

Treatment Summary

Propranolol is a medication used to treat irregular heartbeats, high blood pressure, and glaucoma. It works by blocking the action of adrenaline, a hormone that can cause these medical conditions.

OptiPranolol

is the brand name

Optipranolol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

OptiPranolol

Metipranolol

1989

4

Approved as Treatment by the FDA

Metipranolol, otherwise known as OptiPranolol, is approved by the FDA for 4 uses like Ocular Hypertension and Open Angle Glaucoma (OAG) .

Ocular Hypertension

Helps manage Ocular Hypertension

Open Angle Glaucoma (OAG)

Helps manage Open Angle Glaucoma (OAG)

Open Angle Glaucoma

Helps manage Open Angle Glaucoma (OAG)

Ocular Hypertension

Helps manage Ocular Hypertension

Effectiveness

How Optipranolol Affects Patients

Metipranolol is a drug that helps lower pressure in the eye. It does not have any other effects on the body. It is used to treat ocular hypertension and open-angle glaucoma, conditions that can damage the optic nerve and cause vision loss. Metipranolol lowers pressure in the eye without affecting pupil size or the ability to see clearly at different distances.

How Optipranolol works in the body

Metipranolol works by blocking the beta1 and beta2 adrenergic receptors. This reduces the amount of aqueous humor produced in the eye, as well as slightly increasing its outflow. However, it does not have a significant stimulating effect on the body or any significant local anesthetic or heart-depressing effects.

When to interrupt dosage

The prescribed dosage of Optipranolol is contingent upon the diagnosed condition. The extent of dosage relies upon the method of delivery, as detailed in the accompanying table.

Condition

Dosage

Administration

Open Angle Glaucoma

3.0 mg/mL,

, Solution / drops, Solution / drops - Ophthalmic, Ophthalmic

Ocular Hypertension

3.0 mg/mL,

, Solution / drops, Solution / drops - Ophthalmic, Ophthalmic

Warnings

Optipranolol Contraindications

Condition

Risk Level

Notes

Heart Failure

Do Not Combine

Atrioventricular Block

Do Not Combine

Asthma

Do Not Combine

symptomatic sinus bradycardia

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Asthma

Do Not Combine

There are 20 known major drug interactions with Optipranolol.

Common Optipranolol Drug Interactions

Drug Name

Risk Level

Description

Aliskiren

Minor

Metipranolol may increase the hypotensive activities of Aliskiren.

Ambrisentan

Minor

Metipranolol may increase the hypotensive activities of Ambrisentan.

Angiotensin 1-7

Minor

Metipranolol may increase the hypotensive activities of Angiotensin 1-7.

Azilsartan medoxomil

Minor

Metipranolol may increase the hypotensive activities of Azilsartan medoxomil.

BQ-123

Minor

Metipranolol may increase the hypotensive activities of BQ-123.

Optipranolol Novel Uses: Which Conditions Have a Clinical Trial Featuring Optipranolol?

34 active investigations are assessing the potential of Optipranolol to mitigate Open Angle Glaucoma.

Condition

Clinical Trials

Trial Phases

Ocular Hypertension

10 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

Patient Q&A Section about optipranolol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Metipranolol used for?

"This medicine is used to lower pressure in the eye that is caused by open-angle glaucoma or ocular hypertension. It is a beta-blocker."

Answered by AI

Is Metipranolol discontinued?

"As of right now, are there any brands or generic products of metipranolol still available on the market?"

Answered by AI

What is the generic name for timoptic?

"The drug Timoptic is called timolol in its generic form. The drug Xalatan is called latanoprost in its generic form."

Answered by AI

Clinical Trials for Optipranolol

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We made a collection of clinical trials featuring Optipranolol, we think they might fit your search criteria.
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Have you considered Optipranolol clinical trials?

We made a collection of clinical trials featuring Optipranolol, we think they might fit your search criteria.
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Image of Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham in Birmingham, United States.

AI-Based Screening for Glaucoma

18+
All Sexes
Birmingham, AL

The goal of this clinical trial is to learn if implementation of an eye screening program at Federally Qualified Health Center (FQHC) clinics provides results that participants may have glaucoma, and/or other eye conditions (diabetic retinopathy, cataract, visual acuity impairment). The glaucoma screening will incorporate use of an artificial intelligence (AI)-assisted screening tool. This project is called AI-RONA. The main questions it aims to answer are: * How does this eye screening program compare to the rate of glaucoma and other eye conditions detected at other FQHC clinics where the screening program has not been implemented? * Do particpants who screen positive for these conditions adhere to the physician's recommendation for a follow-up examination by an optometrist or ophthalmologist? * Are referral rates for a follow-up comprehensive eye exam by an optometrist or ophthalmologist similar to those implemented by an ophthalmologist using telemedicine (that is, using the results of the screening to make a diagnosis remotely)? * What is the cost-effectiveness of the AI-assisted screening program in diagnosing glaucoma as compared to a physician-guided program? * Are participants completing the screening satisfied with it? * Are physicians at the FQHC clinics administering the screening satisfied with it? Participants will: * Undergo an ocular screening whose goal is to detect glaucoma, diabetic retinopathy, cataract, and/or impairment in visual acuity. If the screening indicates that participants may have these conditions, participants will be referred for a comprehensive eye examination by an optometrist or ophthalmologist. * Following the screening, participants and physicians will complete a survey on their satisfaction with the program.

Recruiting
Has No Placebo

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham

Cynthia Owsley, PhD

Have you considered Optipranolol clinical trials?

We made a collection of clinical trials featuring Optipranolol, we think they might fit your search criteria.
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