Penicillin G Procaine

Pinta, Erysipelas, Yaws + 24 more

Treatment

9 FDA approvals

7 Active Studies for Penicillin G Procaine

What is Penicillin G Procaine

Procaine benzylpenicillin

The Generic name of this drug

Treatment Summary

Procaine benzylpenicillin is an injectable combination antibiotic. It is a mix of benzylpenicillin, which is naturally occurring and effective against a wide range of organisms, and procaine, a local anesthetic to reduce the pain of injection. Procaine benzylpenicillin is administered by deep intramuscular injection and is slowly absorbed and then hydrolyzed into benzylpenicillin, allowing for a slow release of the drug into the body. This drug is used to treat many infections, especially in veterinary settings, and is the drug of first choice for many infections.

Penicillin G Procaine

is the brand name

Penicillin G Procaine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Penicillin G Procaine

Procaine benzylpenicillin

1948

10

Approved as Treatment by the FDA

Procaine benzylpenicillin, otherwise known as Penicillin G Procaine, is approved by the FDA for 9 uses like presenting as being moderately severe and presenting as being moderately severe to severe .

presenting as being moderately severe

Used to treat presenting as being moderately severe in combination with Benzylpenicillin

presenting as being moderately severe to severe

Used to treat presenting as being moderately severe to severe in combination with Benzylpenicillin

Scarlet Fever

Used to treat Scarlet Fever caused by susceptible streptococci in combination with Benzylpenicillin

Erysipelas

Used to treat Erysipelas caused by susceptible streptococci in combination with Benzylpenicillin

Otitis Media

Used to treat Otitis Media caused by susceptible pneumococci in combination with Benzylpenicillin

Regional Anesthetic Nerve Block

Pneumonia

Used to treat Pneumonia caused by susceptible pneumococci in combination with Benzylpenicillin

Skin Structures and Soft Tissue Infections caused by susceptible streptococci

Used to treat Skin Structures and Soft Tissue Infections caused by susceptible streptococci in combination with Benzylpenicillin

Streptococcus

Used to treat Upper Respiratory Tract Infection caused by susceptible streptococci in combination with Benzylpenicillin

Effectiveness

How Penicillin G Procaine Affects Patients

Procaine benzylpenicillin is an antibiotic used to treat bacteria that are sensitive to penicillin. It works by preventing bacteria from making their cell walls, which makes them unstable and unable to survive. It belongs to a family of antibiotics called penicillins and beta-lactams.

How Penicillin G Procaine works in the body

Procaine benzylpenicillin is converted to penicillin G when it reaches the injection site. Penicillin G attaches to the proteins on bacterial cell walls and stops an enzyme from cross-linking peptides to the peptidoglycan backbone. This eventually causes the bacteria to break apart and die.

When to interrupt dosage

The endorsed measurement of Penicillin G Procaine is contingent upon the recognized condition, including Necrotizing ulcerative gingivostomatitis, Yaws and Regional Anesthetic Nerve Block. The dose can be located in the table below, contingent upon the technique of delivery (e.g. Injection, suspension or Powder, for solution).

Condition

Dosage

Administration

Scarlet Fever

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Streptococcus

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Primary Syphilis

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Pneumonia

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Erysipelas

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Yaws

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Respiratory Tract Infections

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

presenting as being moderately severe to severe

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Skin Structures and Soft Tissue Infections caused by susceptible streptococci

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Scarlet Fever

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Diphtheria

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Rat-Bite Fever

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Pinta

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

prophylaxis of Anthrax

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Non-venereal endemic syphilis

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

presenting as being moderately severe

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Tertiary syphilis

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Anthrax

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Necrotizing ulcerative gingivostomatitis

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Regional Anesthetic Nerve Block

, 1200000.0 [iU]/mL, 600000.0 [iU]/mL, 300000.0 [iU]/mL, 300000.0 units/mL

, Powder, for solution - Intramuscular, Intramuscular, Powder, for solution, Suspension, Injection, suspension, Injection, suspension - Intramuscular, Injection, Injection - Intramuscular, Suspension - Intramuscular

Warnings

Penicillin G Procaine Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Penicillin G Procaine.

Common Penicillin G Procaine Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Procaine benzylpenicillin.

Acrivastine

Minor

Procaine benzylpenicillin may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Procaine benzylpenicillin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Almasilate

Minor

Procaine benzylpenicillin may decrease the excretion rate of Almasilate which could result in a higher serum level.

Antihemophilic factor (recombinant), PEGylated

Minor

Procaine benzylpenicillin may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.

Penicillin G Procaine Toxicity & Overdose Risk

Procaine benzylpenicillin can cause pain, clotting problems, and seizures. Treatment for syphilis can lead to the Jarisch-Herxheimer reaction. Skin rashes, fever, delayed serum sickness, and anaphylactic shock can also occur. The lethal dose for mice and rats is greater than 2000 mg/kg. Overdosing can cause seizures, paralysis, and death. Vomiting and stomach pumping may help if done soon after the injection. Hemodialysis can reduce high blood levels of the drug.

image of a doctor in a lab doing drug, clinical research

Penicillin G Procaine Novel Uses: Which Conditions Have a Clinical Trial Featuring Penicillin G Procaine?

Currently, four active trials are assessing the potential of Penicillin G Procaine in managing Otitis Media caused by susceptible pneumococci, Primary and Tertiary Syphilis.

Condition

Clinical Trials

Trial Phases

Diphtheria

0 Actively Recruiting

Tertiary syphilis

0 Actively Recruiting

prophylaxis of Anthrax

0 Actively Recruiting

Erysipeloid

0 Actively Recruiting

Primary Syphilis

0 Actively Recruiting

Scarlet Fever

0 Actively Recruiting

Respiratory Tract Infections

0 Actively Recruiting

Rat-Bite Fever

0 Actively Recruiting

Scarlet Fever

0 Actively Recruiting

Erysipelas

0 Actively Recruiting

presenting as being moderately severe to severe

0 Actively Recruiting

Yaws

0 Actively Recruiting

Secondary Syphilis

0 Actively Recruiting

presenting as being moderately severe

0 Actively Recruiting

Pinta

0 Actively Recruiting

Urinary Tract Infection (UTI)

6 Actively Recruiting

Phase 1, Phase 3, Phase 4, Phase 2

Pneumonia

0 Actively Recruiting

Erysipelas

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Streptococcus

0 Actively Recruiting

Penicillin G Procaine Reviews: What are patients saying about Penicillin G Procaine?

1.7

Patient Review

6/2/2008

Penicillin G Procaine for Syphilis

Patient Q&A Section about penicillin g procaine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is penicillin G and procaine combined?

"The combination of lidocaine and penicillin is intended to reduce the pain and discomfort associated with a large intramuscular injection of penicillin."

Answered by AI

What is the difference between penicillin G benzathine and procaine?

"Benzathine is a salt form of penicillin G that is less soluble and provides a longer duration of action. Penicillin G procaine is given once daily and injected into the midlateral thigh or upper outer quadrant of the gluteus maximus."

Answered by AI

What is penicillin G procaine used for?

"Penicillin G Procaine is an antibiotic that is injected into a muscle to treat bacterial infections in different areas of the body. It is not effective in treating viral infections, such as the common cold."

Answered by AI

Is procaine penicillin the same as penicillin G?

"Procaine penicillin G is a combination of benzylpenicillin and the local anaesthetic agent procaine. It is slowly absorbed into the body after IM administration and hydrolysed to benzylpenicillin. This allows for a prolonged but low concentration of benzylpenicillin in the body."

Answered by AI

Clinical Trials for Penicillin G Procaine

Image of Harbor UCLA Medical Center - Medicine - Infectious Diseases in Torrance, United States.

Optimized Beta-lactam Dosing for Bacterial Infections

18+
All Sexes
Torrance, CA

The purpose of this study is to evaluate the abilities of Cystatin C (CysC) and CysC-based estimated Glomerular Filtration Rate (eGFR) equations to characterize the pharmacokinetics (PK) profiles of meropenem and cefepime relative to Serum Creatinine (SCR), Serum Creatinine based Equation (SCRE)and iohexol at the population and individual levels in critically ill adult patients with suspected or documented AMR Gram-negative infections. We hypothesize that CysC and CysC-based eGFR equations will characterize the PK profiles of meropenem and cefepime at the population and individual levels with greater accuracy and precision than SCR and SCREs. Iohexol will be administered to patients enrolled in the study and serve as the reference indicator of measured Glomerular Filtration Rate (mGFR), which is the gold standard assessment of kidney function. We hypothesize that the predictive performances of CysC and CysC-based eGFR equations in estimating the PK profiles of meropenem and cefepime at the population and individual levels will be comparable to iohexol. The information obtained in this study will be used to develop PK/pharmacodynamics (PD) optimized meropenem and cefepime dosing schemes based on the renal function biomarker population PK (PopPK) model with the best predictive performance for clinical use in the treatment of critically ill adult patients with suspected or documented AMR Gram-negative infections and varying degrees of renal function. The primary objective of this study is to compare the abilities of renal function biomarkers (CysC, CysC-based eGFR equations, SCR, SCREs) relative to iohexol to characterize the PK profiles of meropenem and cefepime in critically ill adult patients with suspected or documented AMR Gram-negative infections.

Phase 4
Recruiting

Harbor UCLA Medical Center - Medicine - Infectious Diseases (+9 Sites)

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