Radiosurgery for Essential Tremor

Recruiting in Palo Alto (17 mi)

Dr. John Fiveash, MD - Birmingham, AL ...

Overseen byMarkus Bredel, MD, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing a non-surgical radiation treatment to help people with severe tremors from Essential Tremor or Parkinson's Disease who can't have traditional brain surgery. The treatment aims to reduce shaking by targeting specific brain areas with precise radiation. This minimally invasive alternative to traditional brain surgery is designed for treating tremors in conditions like Essential Tremor and Parkinson's Disease.

Eligibility Criteria

This trial is for adults with severe, treatment-resistant shaking (tremor) due to Essential Tremor or Parkinson's Disease who can't have deep brain stimulation because of health issues or personal choice. They should be able to perform daily activities with minimal assistance (ECOG status 0-2).

Inclusion Criteria

All patients must be given written informed consent.

I am 18 years old or older.

I am able to care for myself and up and about more than 50% of my waking hours.

+1 more

Exclusion Criteria

You cannot have an MRI because of a medical reason, such as having a pacemaker.

I have had brain radiation therapy before.

Participant Groups

The study tests a non-invasive procedure called Virtual Cone Radiosurgical Thalamotomy, which targets the brain area causing tremors. It aims to reduce tremors in patients who haven't improved with medication and aren't suitable for surgery.

1Treatment groups

Experimental Treatment

Group I: 130 Gy Radiation & Unframed Virtual ConeExperimental Treatment1 Intervention

130 Gy Virtual Cone Radiosurgery Unframed (Face Mask)