Pulsed Dye Laser Therapy for Burn Scars
Recruiting in Palo Alto (17 mi)
Overseen ByS Logsetty, MD
Age: 18 - 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Manitoba
Must not be taking: Steroid, Interferon
Disqualifiers: Open wound, Active infection, Keloid, others
No Placebo Group
Approved in 2 jurisdictions
Trial Summary
What is the purpose of this trial?The purpose of this study is to determine the effects (good or bad) of pulsed dye laser treatment in burn scar height, texture, redness and pliability in acute burn injury.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Pulsed Dye Laser Therapy for burn scars?
Research shows that Pulsed Dye Laser (PDL) therapy is effective in treating hypertrophic scars, which are thick, raised scars, and can help improve their appearance. It has been used successfully for scars from surgeries and burns, making it a promising option for burn scars as well.
12345Is pulsed dye laser therapy safe for treating scars?
Research indicates that pulsed dye laser therapy is generally safe for treating scars, with most people experiencing only temporary redness and bruising.
12678How is Pulsed Dye Laser Therapy different from other treatments for burn scars?
Pulsed Dye Laser Therapy (PDL) is unique because it uses a specific wavelength of light to target blood vessels in the skin, which can help reduce redness and improve the appearance of hypertrophic (raised) scars. Unlike some other treatments, PDL is non-invasive and can be precisely controlled to minimize damage to surrounding skin.
2491011Eligibility Criteria
This trial is for individuals with skin types Fitzpatrick I-III who have burn scars aged one to six months and live in Winnipeg. It's not suitable for those with open wounds, active infections, prior steroid or interferon scar treatments, or a tendency towards keloid scarring.Inclusion Criteria
Fitzpatrick I-III skin type
Patients with burn scar
Scar age one to 6 months
+1 more
Exclusion Criteria
Patients with established disposition towards keloid scarring
I currently have an active infection.
I currently have an open wound.
+1 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants receive pulsed dye laser therapy to assess its effects on burn scar height, texture, vascularity, and pliability
6 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
The study is examining the effectiveness of pulsed dye laser therapy on improving the height, texture, redness, and pliability of acute burn scars.
2Treatment groups
Active Control
Group I: ProximalActive Control1 Intervention
part of scar proximal to heart
Group II: DistalActive Control1 Intervention
part of scar distal to heart
Pulsed Dye Laser Therapy is already approved in United States, European Union for the following indications:
🇺🇸 Approved in United States as Pulsed Dye Laser Therapy for:
- Port wine stains
- Hemangiomas
- Rosacea
- Telangiectasias
- Keloids
- Hypertrophic scars
- Acne scars
- Burn scars
🇪🇺 Approved in European Union as Pulsed Dye Laser Therapy for:
- Port wine stains
- Hemangiomas
- Rosacea
- Telangiectasias
- Keloids
- Hypertrophic scars
- Acne scars
- Burn scars
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of ManitobaWinnipeg, Canada
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Who Is Running the Clinical Trial?
University of ManitobaLead Sponsor
References
A prospective study to evaluate the treatment effect of pulsed dye laser on thyroidectomy hypertrophic scars using 3D imaging analysis. [2022]The pulsed dye laser (PDL) is an effective modality for preventing and improving hypertrophic scars (HSs). However, the heterogeneity of the parameter settings of the laser and subjective scar assessment methods used in most studies resulting in uncertainty with treatment plans. Therefore, we investigated the treatment effect of the PDL (V-beam; Candela Laser Corporation) on HSs in post-thyroidectomy patients using three-dimensional imaging analysis and intended to provide a systemic and optimal treatment protocol.
Multimodal quantitative analysis of early pulsed-dye laser treatment of scars at a pediatric burn hospital. [2012]The pulsed-dye laser (PDL) is a potential adjunctive therapy for treatment of hyperemic and hypertrophic scars.
Comparison of 532 nm Potassium Titanyl Phosphate Laser and 595 nm Pulsed Dye Laser in the Treatment of Erythematous Surgical Scars: A Randomized, Controlled, Open-Label Study. [2015]The pulsed dye laser (PDL) has long been used for treatment of erythematous and hypertrophic scars. Its effectiveness has been attributed in large part to its vascular-specificity. The vascular-specific potassium titanyl phosphate (KTP) laser has also been reported to be clinically effective for scars, but has not been compared to the PDL.
Energy density and numbers of treatment affect response of keloidal and hypertrophic sternotomy scars to the 585-nm flashlamp-pumped pulsed-dye laser. [2007]The 585-nm flashlamp-pumped pulsed-dye laser (PDL) has proven to be the treatment of choice for certain keloids and hypertrophic scars, but the precise fluence, numbers of treatment, and treatment interval remain anecdotal.
Prevention or treatment of hypertrophic burn scarring: a review of when and how to treat with the pulsed dye laser. [2022]The purpose of this review is to investigate the use of Pulsed Dye Laser (PDL) as a therapeutic tool for hypertrophic burns scarring. The difference between keloids and hypertrophic scars is first described. The review then outlines the progress and assessment of hypertrophic scars for burns patients and the problem of their clinical management. The assessment using both objective and subjective measurements for complete account of hypertrophic scars is explained. The efficacy of PDL for both prevention and treatment is summarised for all hypertrophic scarring and the various laser treatment protocols in previous research is studied. The differentiation between prevention and treatment is discussed in relation to scar duration and the need for prevention rather than treatment is then proposed for intervention using PDL. The paper concludes with recommendations for future research through a prospective randomised, controlled study using 595 nm PDL in the prevention of scars with less than 6 month duration.
Efficacy of pulsed dye laser combined with fractional CO2 laser in the treatment of pediatric burn scars. [2023]Label="OBJECTIVE">The present study aimed to investigate the efficacy and safety of pulsed dye laser (PDL) combined with fractional CO2 laser in the treatment of burn scars in pediatric patients.
Efficacy and safety of pulsed dye laser for the treatment of surgical scars: a systematic review and meta-analysis. [2022]Various clinical trials have explored whether the pulsed dye laser (PDL) method is safe to treat scars, especially surgical scars. However, comprehensive evidence confirming the exact outcomes of PDL for treating surgical scars is lacking. The efficacy and safety of PDL in the treatment of surgical scars were determined through a review of several studies. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched, and the main clinical outcomes were Vancouver Scar Scale (VSS) scores in terms of pigmentation, vascularity, pliability, and height. Review Manager 5.4 software was used for statistical analyses of the data; we chose a standardized mean difference (SMZ) to present the results with 95% confidence interval (CI). Overall, seven randomized controlled trials were used for this meta-analysis, all of these papers used 585 nm or 595 nm PDL with 7 mm or 10 mm spot size and a fluence of 3.5 to 10 J/cm2 for treating surgical scars; besides, the pulse duration ranged from 450 μs to 10 ms. We found that PDL significantly resulted in decreased VSS scores (P = 0.02) in four aspects: pigmentation (P = 0.0002), vascularity (P < 0.00001), pliability (P = 0.0002), and height (P = 0.0002). Moreover, scar improvement was similar when using 585 nm and 595 nm PDL in terms of pigmentation (P = 0.76), vascularity (P = 0.34), pliability (P = 0.64), and height (P = 0.57). Furthermore, our review indicated that PDL has no obvious adverse effects for most people, except transitory erythema and purpura. The meta-analysis showed that both 585 nm and 595 nm PDL therapy can effectively reduce the VSS score, suggesting that PDL can be a safe and effective method for the treatment of surgical scars.
Pulsed dye laser in burn scars: current concepts and future directions. [2015]Hypertrophic scarring after partial-thickness burns is common, resulting in raised, erythematous, pruritic, and contracted scars. Treatment of hypertrophic scars, especially on the face, is challenging and has high failure rates. Excisional treatment has morbidity and can create iatrogenic deformities. After an extensive experience over 10 years with laser therapy for the treatment of difficult scars, the pulsed dye laser (PDL) has emerged as a successful alternative to excision in patients with hypertrophic burn scars. Multiple studies have shown its ability to decrease scar erythema and thickness while significantly decreasing pruritus and improving the cosmetic appearance of the scar. The history of laser therapy and the mechanism of action and results of the PDL in burn scars will be reviewed. The PDL should become an integral part of the management of burn scarring and will significantly decrease the need for excisional surgery.
Treatment of vascular skin lesions with the variable-pulse 595 nm pulsed dye laser. [2022]In the dermatology field, variable-pulse 595 nm pulsed dye lasers (PDLs) are now being widely used to treat vascular skin lesions. However, there is little information available on variable-pulse 595 nm PDL treatment of dark-skinned patients.
Laser scar revision: comparison of CO2 laser vaporization with and without simultaneous pulsed dye laser treatment. [2019]Over the past decade, the 585-nm pulsed dye laser (PDL) has been used successfully to treat a variety of cutaneous vascular lesions as well as hypertrophic scars. Laser scar revision has been revolutionized by the recent development of high-energy, pulsed carbon dioxide (CO2) laser systems. These new CO2 lasers allow controlled vaporization of thin layers of skin while minimizing damage to surrounding dermal structures.
Effect of pulse width of a 595-nm flashlamp-pumped pulsed dye laser on the treatment response of keloidal and hypertrophic sternotomy scars. [2022]Flashlamp-pumped pulsed dye lasers (PDLs) have successfully treated keloidal and hypertrophic scars.