Pletal

Intermittent Claudication
Treatment
1 FDA approval
7 Active Studies for Pletal

What is Pletal

CilostazolThe Generic name of this drug
Treatment SummaryCilostazol is a medication used to treat intermittent claudication, a condition caused by decreased blood flow to the legs. It is a quinolinone derivative and antiplatelet agent that helps widen blood vessels, increasing blood flow and relieving symptoms of claudication. The drug is marketed under the brand name Pletal and works by inhibiting platelet aggregation and reducing calcium-induced contractions.
Pletalis the brand name
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Pletal Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pletal
Cilostazol
1999
68

Approved as Treatment by the FDA

Cilostazol, also called Pletal, is approved by the FDA for 1 uses which include Intermittent Claudication .
Intermittent Claudication

Effectiveness

How Pletal Affects PatientsCilostazol helps reduce the pain in the legs that is caused by reduced blood flow (intermittent claudication). It does this by allowing people to walk farther distances without feeling pain from the reduced blood flow.
How Pletal works in the bodyCilostazol increases levels of a compound called cAMP within blood vessels and platelets. This raises levels of cAMP, which inhibits platelet aggregation and leads to vasodilation. Cilostazol does this by blocking the action of an enzyme that breaks down cAMP.

When to interrupt dosage

The suggested measure of Pletal relies upon the determined affliction. The degree of dosage varies in accordance with the technique of delivery (e.g. Tablet or Tablet - Oral) outlined in the table beneath.
Condition
Dosage
Administration
Intermittent Claudication
50.0 mg, , 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet - Conjunctival; Oral, Conjunctival; Oral

Warnings

Pletal has one known contraindication, and its employment should be avoided when afflicted with any of the conditions given in the following table.Pletal Contraindications
Condition
Risk Level
Notes
Congestive Heart Failure
Do Not Combine
There are 20 known major drug interactions with Pletal.
Common Pletal Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Cilostazol is combined with Abrocitinib.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Cilostazol.
Amrinone
Major
The risk or severity of congestive heart failure, bleeding, hypotension, and Tachycardia can be increased when Cilostazol is combined with Amrinone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Cilostazol.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Cilostazol.
Pletal Toxicity & Overdose RiskAn overdose of cilostazol may cause a severe headache, diarrhea, low blood pressure, fast heartbeat, and abnormal heart rhythms. The lowest toxic dose in mice, rats, and dogs is greater than 5.0g/kg, 2.0g/kg, and 2.0g/kg, respectively.
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Pletal Novel Uses: Which Conditions Have a Clinical Trial Featuring Pletal?

9 active trials are assessing the potential of Pletal in providing relief from Intermittent Claudication.
Condition
Clinical Trials
Trial Phases
Intermittent Claudication
7 Actively Recruiting
Not Applicable, Phase 1, Phase 3, Phase 2

Pletal Reviews: What are patients saying about Pletal?

5Patient Review
1/5/2013
Pletal for Leg Pain when Walking; Absent at Rest
I was having a lot of trouble walking even short distances before beginning this medication. Now, I can walk for long periods of time without issue. It's been a huge difference and has greatly improved my quality of life.
5Patient Review
10/10/2013
Pletal for Leg Pain when Walking; Absent at Rest
I was diagnosed with PAD and have to walk regularly as a result. This medication has been helping me immensely--I'm feeling back to my old self again!
4.3Patient Review
6/26/2017
Pletal for Leg Pain when Walking; Absent at Rest
My husband's cramps have stopped since he started taking this medication. However, about an hour after he takes it, he doesn't feel very well. I'm hoping that as he continues to take the drug, he will become more tolerant of the side effects.
4.3Patient Review
9/27/2012
Pletal for Leg Pain when Walking; Absent at Rest
I've been using Pletel for just over two years and it's been working well for me. I think part of the reason it works so well is because I'm constantly walking around at work.
4.3Patient Review
6/16/2012
Pletal for Leg Pain when Walking; Absent at Rest
I've been experiencing hot flashes, headaches and lightheadedness.
3.7Patient Review
9/13/2021
Pletal for Leg Pain when Walking; Absent at Rest
This medication has been a game-changer for me. I've been dealing with calf pain for 10 years, and this drug combined with walking has finally provided some relief. The headaches were a bit of a problem at first, but they went away after a couple of weeks and I haven't had any issues since then.
3.3Patient Review
7/9/2013
Pletal for Leg Pain when Walking; Absent at Rest
After walking for just five minutes, I was in a lot of pain.
3.3Patient Review
3/2/2014
Pletal for Leg Pain when Walking; Absent at Rest
I've experienced less pain in my legs since taking this medication, but it's not completely gone.
2.3Patient Review
6/14/2012
Pletal for Leg Pain when Walking; Absent at Rest
I've been taking this drug for a while now and I haven't noticed any difference.
2.3Patient Review
3/27/2012
Pletal for Leg Pain when Walking; Absent at Rest
2.3Patient Review
6/3/2014
Pletal for Leg Pain when Walking; Absent at Rest
I'm 74 years old and I've been on this medication for over two years with no improvement. I'll stop taking it when my prescription runs out.
2Patient Review
12/11/2013
Pletal for Leg Pain when Walking; Absent at Rest
I've just started taking Pletal for my leg pain and so far I'm not seeing too much of an improvement.
2Patient Review
9/9/2013
Pletal for Leg Pain when Walking; Absent at Rest
I'm not entirely sure if this is working for me or not.
1.7Patient Review
9/27/2012
Pletal for Leg Pain when Walking; Absent at Rest
This medication gave me a headache.
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Patient Q&A Section about pletal

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of the drug Pletal?

"The following are symptoms of a bad reaction to the medication: headache, diarrhea, vomiting, abnormal stools, dizziness, weakness, fast or pounding heartbeats, palpitations."

Answered by AI

Is Pletal blood thinner?

"It works by preventing blood cells called platelets from sticking together and forming harmful clots. It also widens blood vessels in the legs, which increases blood flow and helps to prevent clots from forming."

Answered by AI

What is medication Pletal used for?

"PLETAL is a prescription medicine used to reduce the symptoms of intermittent claudication, which can increase your ability to walk further distances."

Answered by AI

What type of medication is Pletal?

"Pletal is a medication that dilates blood vessels and improves circulation by preventing platelets from sticking together and clotting."

Answered by AI

Clinical Trials for Pletal

Have you considered Pletal clinical trials? We made a collection of clinical trials featuring Pletal, we think they might fit your search criteria.
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