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What is Ticagrelor
TicagrelorThe Generic name of this drug
Treatment SummaryTicagrelor, also known as AZD6140, is a medication used to treat and prevent blood clots in patients with heart conditions. It is a derivative of ADP that works by blocking the P2Y12 receptor. Ticagrelor is sold by AstraZeneca under the brand names Brilinta in the US and Brilique or Possia in the EU. It was approved by the European Medicines Agency (EMA) in 2010 and the US Food and Drug Administration (FDA) in 2011.
Brilintais the brand name
Ticagrelor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Brilinta
Ticagrelor
2011
7
Effectiveness
How Ticagrelor Affects PatientsTicagrelor is a drug used to reduce the risk of heart attack and stroke by preventing blood clots from forming. It is taken twice a day and is generally well tolerated at higher doses. Patients should be warned about potential side effects, such as bleeding, shortness of breath, and slow heart rate.
How Ticagrelor works in the bodyTicagrelor prevents a specific type of receptor from activating and causing platelet aggregation. When this receptor is blocked, it reduces the risk of blood clots forming, which can lead to a reduction in heart attacks and strokes.
When to interrupt dosage
The recommended dosage of Ticagrelor is contingent upon the diagnosed condition, including Stent Placement, Heart Attack and Stroke. The quantity of dosage changes depending on the method of delivery outlined in the table below.Condition
Dosage
Administration
High Ischemic Risk
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Stroke
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Thrombosis
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Acute Chest Syndrome
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Transient Ischemic Attack (TIA)
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Coronary Disease
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Heart Attack
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
High Risk
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Cardiovascular Mortality
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Ischemic Stroke
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Stent Stenosis
, 90.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating
Warnings
Ticagrelor has three contraindications, and it should not be taken when experiencing any of the circumstances outlined in the following table.Ticagrelor ContraindicationsCondition
Risk Level
Notes
Intracranial Hemorrhage
Do Not Combine
Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ticagrelor may interact with Pulse Frequency
Common Ticagrelor Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Ticagrelor.
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Ticagrelor is combined with Abrocitinib.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Ticagrelor.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Ticagrelor.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Ticagrelor.
Ticagrelor Toxicity & Overdose RiskSigns of an overdose on ticagrelor include bleeding, nausea, vomiting, diarrhea, and pauses in the heartbeat. Treatment for overdose includes monitoring the patient's heart rate and providing supportive care. Dialysis is not expected to be effective in removing ticagrelor from the bloodstream because it binds strongly to proteins.
Ticagrelor Novel Uses: Which Conditions Have a Clinical Trial Featuring Ticagrelor?
84 active trials are evaluating the potential of Ticagrelor in providing relief from Acute Chest Syndrome, Cardiovascular Mortality and Myocardial Infarction.Condition
Clinical Trials
Trial Phases
Cardiovascular Mortality
0 Actively Recruiting
Acute Chest Syndrome
3 Actively Recruiting
Not Applicable, Phase 2
High Risk
1 Actively Recruiting
Phase 1
Thrombosis
0 Actively Recruiting
Transient Ischemic Attack (TIA)
3 Actively Recruiting
Not Applicable, Phase 4
Coronary Disease
1 Actively Recruiting
Not Applicable
Heart Attack
27 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1
Stent Stenosis
0 Actively Recruiting
High Ischemic Risk
0 Actively Recruiting
Stroke
9 Actively Recruiting
Phase 4, Not Applicable
Ischemic Stroke
24 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable
Ticagrelor Reviews: What are patients saying about Ticagrelor?
5Patient Review
4/8/2014 So far, this medication has been working great for me. I have had a few bruises, but that's the extent of the side effects I've experienced.
4.7Patient Review
5/20/2015 I've been using this medication since July and it has helped me a lot. I've had two stents put in as a result of my previous health problems.
4Patient Review
2/24/2013 I've only been taking this for less than a month, but I haven't had any negative experiences yet.
3.3Patient Review
8/10/2021 I had some bruising, but nothing too severe. I was able to go back to my regular activities quickly.
3Patient Review
9/23/2011 I've only recently started taking this medication, but so far it's been okay.
2.7Patient Review
11/3/2013 I had a stent placed in my one 60% blocked artery following a heart attack three weeks ago. I have been feeling heavy breathing and had a massive nose bleed last week where the artery in my nose burst and couldn't be stopped. I had to get emergency e,n,t specialist at Auckland Hospital who was able to stop the bleed after two days. This is a very risky drug, in my opinion.
2.3Patient Review
8/13/2015 This has had a negative effect on my breathing.
1Patient Review
9/24/2019 I felt very heavy breathing and short of breath after taking the first dose. I'm afraid of the possible side effects.
Patient Q&A Section about ticagrelor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is ticagrelor a beta blocker?
"The active drug in Brilinta is not a beta-blocker; it is ticagrelor, an antiplatelet drug."
Answered by AI
Is ticagrelor an anticoagulant?
"There are two types of anticoagulants: Plavix (clopidogrel bisulfate) and Brilinta (ticagrelor). These blood thinners inhibit aspects of blood clotting and are used to treat patients with acute coronary syndrome, heart attack (myocardial infarction), peripheral vascular disease, and ischemic strokes."
Answered by AI
Is ticagrelor same as aspirin?
"The new study found that ticagrelor is not more effective than aspirin in preventing cardiovascular events 90 days after an initial stroke. This is an important finding, as it provides new insights into the best course of treatment for patients who have experienced a stroke or TIA."
Answered by AI
Is Plavix the same as ticagrelor?
"Ticagrelor, or Brilinta, may be slightly more effective than Plavix in reducing the percentage of cardiovascular death, myocardial infarction, or stroke in the first year of treatment. However, patients taking Brilinta were more likely to experience difficulty breathing as a side effect compared to those taking Plavix."
Answered by AI
What is ticagrelor drug used for?
"Ticagrelor helps to prevent the formation of blood clots by making it easier for blood to flow through the veins. This is especially helpful for people who are at increased risk for blood clots."
Answered by AI