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What is Premarin
Conjugated estrogensThe Generic name of this drug
Treatment SummaryConjugated estrogens are a combination of female hormones used to treat a variety of conditions, including osteoporosis. This medication is usually made from pregnant mare's urine, which is then combined with a sodium sulfate to make it more water-soluble. The mixture contains estrone sulfate, equilin sulfate, 17-alpha-dehydroequilenin sulfate, equilenin sulfate, 17-alpha and 17-beta-dihydroequilenin sulfate, 17-alpha-estradiolsulfate, and 17-beta-estradiol
Premarinis the brand name
Premarin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Premarin
Conjugated estrogens
1956
60
Approved as Treatment by the FDA
Conjugated estrogens, also known as Premarin, is approved by the FDA for 13 uses including Premature Menopause and Osteoporosis .Premature Menopause
Osteoporosis
Used to treat Osteoporosis in combination with Bazedoxifene
Palliative Treatment
Advance Directives
Hypogonadism
Premature Ovarian Failure (POF)
Osteoporosis
Used to treat Osteoporosis in combination with Bazedoxifene
Hot flashes
Used to treat Menopause in combination with Methyltestosterone
hypoestrogenism
Low Testosterone
Atrophy of vulva
Vasomotor System
Used to treat Moderate to Severe Vasomotor Symptoms in combination with Methyltestosterone
female castration
Effectiveness
How Premarin Affects PatientsEstrogens attach to the estrogen receptor, which triggers a series of steps and leads to certain genes being turned on. This is known to be similar in strength to the hormone estrone, and has effects on the bones and cardiovascular system. After taking conjugated estrogens, people typically experience more stable blood pressure, better urinary function, and balanced development of female hormones. It also helps with bone loss by preventing the breakdown of bones and restoring the balance. Finally, it also reduces testosterone levels and luteinizing hormone.
How Premarin works in the bodyConjugated estrogens work by binding to estrogen receptors found in different tissues. This binding triggers the production of DNA, RNA, and proteins in those tissues. This then reduces the release of certain hormones from the brain. The exact way in which conjugated estrogens work varies depending on the specific component of the product.
When to interrupt dosage
The prescribed quantity of Premarin is contingent upon the determined condition, such as severe Dyspareunia, female castration and moderate Dyspareunia. The dose varies as per the method of delivery (e.g. Powder, for solution - Intramuscular; Intravenous or Oral) featured in the table below.Condition
Dosage
Administration
Atrophic Vaginitis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Advance Directives
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Low Testosterone
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
hypoestrogenism
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
severe Dyspareunia
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Palliative Treatment
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
hormonal imbalance
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Osteoporosis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Dyspareunia
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Atrophy of vulva
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Hot flashes
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Metastatic Breast Cancer
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Estrogen Replacement Therapy
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Premature Menopause
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Uterine hemorrhage
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Vasomotor System
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Vulvitis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Organic Disease
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Vulvitis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Balanitis Xerotica Obliterans
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Warnings
Premarin has fourteen contraindications. It should not be administered alongside the conditions delineated in the following table.Premarin ContraindicationsCondition
Risk Level
Notes
Pulmonary Embolism
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Antithrombin III Deficiency
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Protein C Deficiency
Do Not Combine
Thrombophilia
Do Not Combine
Breast
Do Not Combine
Liver Dysfunction
Do Not Combine
Protein Deficiency
Do Not Combine
Pulmonary Embolism
Do Not Combine
Common Premarin Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Conjugated estrogens.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Conjugated estrogens.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Conjugated estrogens.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Conjugated estrogens.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Conjugated estrogens.
Premarin Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats is more than 5000mg/kg. Symptoms of overdosing have not been reported, but some people have experienced nausea, vomiting, and abnormal bleeding (mostly in women). Taking this drug for an extended period of time may increase one's risk of developing certain types of cancer, such as breast, uterine, cervical, vaginal, testicular, and liver cancer.
Premarin Novel Uses: Which Conditions Have a Clinical Trial Featuring Premarin?
42 active clinical trials are currently being conducted to assess the potential of Premarin to combat Kraurosis Vulvae, Vasomotor System disorders and severe Dyspareunia.Condition
Clinical Trials
Trial Phases
Palliative Treatment
1 Actively Recruiting
Not Applicable
Osteoporosis
33 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Metastatic Breast Cancer
1 Actively Recruiting
Phase 1, Phase 2
Atrophic Vaginitis
1 Actively Recruiting
Not Applicable
Hot flashes
17 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2
Dyspareunia
4 Actively Recruiting
Not Applicable
Estrogen Replacement Therapy
0 Actively Recruiting
Low Testosterone
5 Actively Recruiting
Phase 4, Phase 2, Phase 1
Atrophy of vulva
1 Actively Recruiting
Not Applicable
hormonal imbalance
0 Actively Recruiting
severe Dyspareunia
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Vasomotor System
0 Actively Recruiting
Advance Directives
0 Actively Recruiting
Organic Disease
0 Actively Recruiting
female castration
0 Actively Recruiting
Uterine hemorrhage
0 Actively Recruiting
Balanitis Xerotica Obliterans
0 Actively Recruiting
Vulvitis
0 Actively Recruiting
Vulvitis
0 Actively Recruiting
Premarin Reviews: What are patients saying about Premarin?
5Patient Review
10/18/2016 This cream has completely changed my life for the better. I was in so much pain that I had given up on sex, but now thanks to premarin I'm enjoying a healthy and active sex life again.
4Patient Review
9/10/2017 I've been struggling with vaginal dryness and painful intercourse for years. I tried different treatments on and off, but none of them really worked well enough to make a significant difference. Recently, I decided to experiment on my own, and I'm glad I did! After just two weeks of using this treatment every day, my libido is great and there's no more pain during sex.
4Patient Review
10/31/2017 Though this medication has helped me, I've had several instances of extreme throat swelling. Has anyone else experienced this side effect?
3.7Patient Review
7/1/2022 The product is extremely over price and you get very little of the product in the tube due to amount needed to achieve satisfaction. Over $400 per tube and insurance will pay only small amunt and restricts doses covered. I pay mostly out of pocket.
3.7Patient Review
7/12/2017 You can save a lot of money by getting this cream compounded at your local pharmacy.
Patient Q&A Section about premarin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Premarin used for?
"This medication contains a female hormone that helps reduce symptoms of menopause, such as hot flashes and vaginal dryness. These symptoms are caused by the body making less estrogen."
Answered by AI
Is Premarin made from horse urINe?
"Premarin is a highly prescribed estrogen that can be taken orally or as a topical cream. This estrogen product is made from the urine of pregnant horses. It has been used as a hormone replacement therapy for postmenopausal women in the USA since 1942."
Answered by AI
Why was Premarin taken off the market?
"A government study of Wyeth's hormone replacement drugs, Prempro and Premarin, was discontinued in 2002 when new evidence suggested that taking Prempro heightened the risk of breast cancer, coronary heart disease, stroke, and pulmonary embolism, and that Premarin increased risk of stroke."
Answered by AI
What does Premarin do to your body?
"Hormone replacement therapy (HRT) containing the hormone estrogen in the form known as conjugated estrogens is a type of PREMARIN treatment that helps relieve the discomfort many women feel during and after menopause, including symptoms such as "hot flushes", sweating and vaginal dryness."
Answered by AI