Premarin

Atrophic Vaginitis, Low Testosterone, Osteoporosis + 19 more

Treatment

13 FDA approvals

20 Active Studies for Premarin

What is Premarin

Conjugated estrogens

The Generic name of this drug

Treatment Summary

Conjugated estrogens are a combination of female hormones used to treat a variety of conditions, including osteoporosis. This medication is usually made from pregnant mare's urine, which is then combined with a sodium sulfate to make it more water-soluble. The mixture contains estrone sulfate, equilin sulfate, 17-alpha-dehydroequilenin sulfate, equilenin sulfate, 17-alpha and 17-beta-dihydroequilenin sulfate, 17-alpha-estradiolsulfate, and 17-beta-estradiol

Premarin

is the brand name

image of different drug pills on a surface

Premarin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Premarin

Conjugated estrogens

1956

60

Approved as Treatment by the FDA

Conjugated estrogens, also known as Premarin, is approved by the FDA for 13 uses including Premature Menopause and Osteoporosis .

Premature Menopause

Osteoporosis

Used to treat Osteoporosis in combination with Bazedoxifene

Advance Directives

Osteoporosis

Used to treat Osteoporosis in combination with Bazedoxifene

Atrophy of vulva

Palliative Treatment

Premature Ovarian Failure (POF)

Hypogonadism

Hot flashes

Used to treat Menopause in combination with Methyltestosterone

hypoestrogenism

Low Testosterone

Vasomotor System

Used to treat Moderate to Severe Vasomotor Symptoms in combination with Methyltestosterone

female castration

Effectiveness

How Premarin Affects Patients

Estrogens attach to the estrogen receptor, which triggers a series of steps and leads to certain genes being turned on. This is known to be similar in strength to the hormone estrone, and has effects on the bones and cardiovascular system. After taking conjugated estrogens, people typically experience more stable blood pressure, better urinary function, and balanced development of female hormones. It also helps with bone loss by preventing the breakdown of bones and restoring the balance. Finally, it also reduces testosterone levels and luteinizing hormone.

How Premarin works in the body

Conjugated estrogens work by binding to estrogen receptors found in different tissues. This binding triggers the production of DNA, RNA, and proteins in those tissues. This then reduces the release of certain hormones from the brain. The exact way in which conjugated estrogens work varies depending on the specific component of the product.

When to interrupt dosage

The prescribed quantity of Premarin is contingent upon the determined condition, such as severe Dyspareunia, female castration and moderate Dyspareunia. The dose varies as per the method of delivery (e.g. Powder, for solution - Intramuscular; Intravenous or Oral) featured in the table below.

Condition

Dosage

Administration

Estrogen Replacement Therapy

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Palliative Treatment

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Vulvitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

hypoestrogenism

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Metastatic Breast Cancer

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Dyspareunia

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Hot flashes

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

severe Dyspareunia

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Atrophy of vulva

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Low Testosterone

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Vulvitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Vulvitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Atrophic Vaginitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Advance Directives

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Osteoporosis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

hormonal imbalance

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Premature Menopause

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Uterine hemorrhage

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Vasomotor System

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Organic Disease

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Injection, powder, lyophilized, for solution, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, sugar coated - Oral, Tablet, sugar coated, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet - Oral, Kit; Tablet, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit, Kit - Oral

Warnings

Premarin has fourteen contraindications. It should not be administered alongside the conditions delineated in the following table.

Premarin Contraindications

Condition

Risk Level

Notes

Pulmonary Embolism

Do Not Combine

estrogen-dependent neoplasia

Do Not Combine

Antithrombin III Deficiency

Do Not Combine

undiagnosed abnormal genital bleeding

Do Not Combine

Breast Cancer

Do Not Combine

Thromboembolism

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Protein C Deficiency

Do Not Combine

Thrombophilia

Do Not Combine

Breast

Do Not Combine

Liver Dysfunction

Do Not Combine

Protein Deficiency

Do Not Combine

Pulmonary Embolism

Do Not Combine

There are 20 known major drug interactions with Premarin.

Common Premarin Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Conjugated estrogens.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Conjugated estrogens.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Conjugated estrogens.

Anastrozole

Major

The therapeutic efficacy of Anastrozole can be decreased when used in combination with Conjugated estrogens.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Conjugated estrogens.

Premarin Toxicity & Overdose Risk

The lowest toxic dose of the drug in rats is more than 5000mg/kg. Symptoms of overdosing have not been reported, but some people have experienced nausea, vomiting, and abnormal bleeding (mostly in women). Taking this drug for an extended period of time may increase one's risk of developing certain types of cancer, such as breast, uterine, cervical, vaginal, testicular, and liver cancer.

image of a doctor in a lab doing drug, clinical research

Premarin Novel Uses: Which Conditions Have a Clinical Trial Featuring Premarin?

42 active clinical trials are currently being conducted to assess the potential of Premarin to combat Kraurosis Vulvae, Vasomotor System disorders and severe Dyspareunia.

Condition

Clinical Trials

Trial Phases

Estrogen Replacement Therapy

0 Actively Recruiting

Palliative Treatment

1 Actively Recruiting

Phase 3

Osteoporosis

27 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 3, Phase 2

Metastatic Breast Cancer

1 Actively Recruiting

Phase 1, Phase 2

Atrophic Vaginitis

1 Actively Recruiting

Not Applicable

Hot flashes

19 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3

Dyspareunia

0 Actively Recruiting

Low Testosterone

6 Actively Recruiting

Phase 4, Phase 2, Phase 1

Atrophy of vulva

1 Actively Recruiting

Not Applicable

hormonal imbalance

0 Actively Recruiting

severe Dyspareunia

0 Actively Recruiting

hypoestrogenism

1 Actively Recruiting

Phase 4

Vasomotor System

0 Actively Recruiting

Advance Directives

0 Actively Recruiting

Organic Disease

0 Actively Recruiting

female castration

0 Actively Recruiting

Uterine hemorrhage

0 Actively Recruiting

Balanitis Xerotica Obliterans

0 Actively Recruiting

Vulvitis

0 Actively Recruiting

Vulvitis

0 Actively Recruiting

Premarin Reviews: What are patients saying about Premarin?

5

Patient Review

10/18/2016

Premarin for Painful Sexual Intercourse due to Menopause

This cream has completely changed my life for the better. I was in so much pain that I had given up on sex, but now thanks to premarin I'm enjoying a healthy and active sex life again.

4

Patient Review

9/10/2017

Premarin for Painful Sexual Intercourse due to Menopause

I've been struggling with vaginal dryness and painful intercourse for years. I tried different treatments on and off, but none of them really worked well enough to make a significant difference. Recently, I decided to experiment on my own, and I'm glad I did! After just two weeks of using this treatment every day, my libido is great and there's no more pain during sex.

4

Patient Review

10/31/2017

Premarin for Postmenopausal Urethral Atrophy

Though this medication has helped me, I've had several instances of extreme throat swelling. Has anyone else experienced this side effect?

3.7

Patient Review

7/1/2022

Premarin for Painful Sexual Intercourse due to Menopause

The product is extremely over price and you get very little of the product in the tube due to amount needed to achieve satisfaction. Over $400 per tube and insurance will pay only small amunt and restricts doses covered. I pay mostly out of pocket.

3.7

Patient Review

7/12/2017

Premarin for Painful Sexual Intercourse due to Menopause

You can save a lot of money by getting this cream compounded at your local pharmacy.

3

Patient Review

5/27/2018

Premarin for Painful Sexual Intercourse due to Menopause

I saw an increase in water retention after only one week of taking this medication. As a result, I've reduced my dosage in order to find the best balance between less water retention and improved vaginal dryness.

3

Patient Review

4/10/2017

Premarin for Postmenopausal Urethral Atrophy

The applicator is very difficult to use. It doesn't attach to the tube well and you have to hold it while trying to squeeze the cream out, which is hard because the plunger is too small. Most of the cream stays in the tube.

3

Patient Review

6/25/2020

Premarin for Painful Sexual Intercourse due to Menopause

The effects of this treatment don't last long after application.

2.7

Patient Review

5/1/2019

Premarin for Painful Sexual Intercourse due to Menopause

I've only been using this for a short while due to pain during sex, but I haven't had the opportunity to test it out yet as my husband is away half the week. So far, no difference that I can tell. The pharmacist did help me find a coupon so it's not too expensive, though.

2.7

Patient Review

11/12/2017

Premarin for Vaginal Inflammation due to Loss of Hormone Stimulation

My doctor only prescribed this estrogen hormonal therapy, which is quite expensive. A lot of the cream is wasted since it's flushed down the toilet.

2.3

Patient Review

8/28/2019

Premarin for Postmenopausal Urethral Atrophy

I had two abnormal mammograms within two years of using this product. I'm still waiting on the results of the second one. My advice would be to stop using this if you have one bad mammogram.

2

Patient Review

9/4/2019

Premarin for Painful Sexual Intercourse due to Menopause

I used Premarin for 3 months, but when I learned about the horrible conditions that the mares on Premarin farms are subjected to, I stopped immediately. To my surprise, I realized that I didn't really need it and could live very well without it. There were no bad side effects either...and I feel so good not being a part of the Premarin industry.

1.7

Patient Review

11/10/2019

Premarin for Painful Sexual Intercourse due to Menopause

This treatment is driving me insane. One day I'm fine, the next day I'm okay, and by the third day I want to cry. I'm not sure if this is going to help me sexually. I haven't had sex in such a long time. It's not pleasant because you deal with pain. Another thing, I just read about the mares and the suffering these poor things go through.I'm going to ask my doctor to give me something different. I don't need a mare to suffer like I'm suffering, so I'll try something else.

1.7

Patient Review

11/16/2019

Premarin for Wasting of Tissues of the Vulva

I'm thankful that I live in a country with socialized healthcare. This medication only cost me $35.79, and the government covered 75% of that because I'm over 65.

1

Patient Review

2/17/2022

Premarin for Painful Sexual Intercourse due to Menopause

The prescribed amount is too small to insert and stay put. Additionally, it caused itching when some did stay in place.

1

Patient Review

1/21/2020

Premarin for Painful Sexual Intercourse due to Menopause

I found out about how this company mistreats pregnant horses and kills their babies for profit, and it made me so angry that I will never use their products again.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about premarin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Premarin used for?

"This medication contains a female hormone that helps reduce symptoms of menopause, such as hot flashes and vaginal dryness. These symptoms are caused by the body making less estrogen."

Answered by AI

Is Premarin made from horse urINe?

"Premarin is a highly prescribed estrogen that can be taken orally or as a topical cream. This estrogen product is made from the urine of pregnant horses. It has been used as a hormone replacement therapy for postmenopausal women in the USA since 1942."

Answered by AI

Why was Premarin taken off the market?

"A government study of Wyeth's hormone replacement drugs, Prempro and Premarin, was discontinued in 2002 when new evidence suggested that taking Prempro heightened the risk of breast cancer, coronary heart disease, stroke, and pulmonary embolism, and that Premarin increased risk of stroke."

Answered by AI

What does Premarin do to your body?

"Hormone replacement therapy (HRT) containing the hormone estrogen in the form known as conjugated estrogens is a type of PREMARIN treatment that helps relieve the discomfort many women feel during and after menopause, including symptoms such as "hot flushes", sweating and vaginal dryness."

Answered by AI

Clinical Trials for Premarin

Image of VA Greater Los Angeles Healthcare System, West Los Angeles, CA in West Los Angeles, United States.

EBQI Strategies for Women's Health

Any Age
All Sexes
West Los Angeles, CA

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Waitlist Available
Has No Placebo

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Erin P Finley, PhD MPH

Image of UC San Diego in San Diego, United States.

Epione Device for Bone Conditions

18+
All Sexes
San Diego, CA

The goal of this investigational device exemption is to evaluate the Epione assistance for introducer placement during percutaneous procedures in musculo-skeletic (MSK) structures of the pelvis and the spine in adults. The main question is the determination of the rate of feasible procedures assisted by the Epione device Participants will undergo their procedure(s) as planned by their physician. If they accept to participate to the study, the differences with standard of care will be: * The use of the Epione device to place the introducer(s), instead of freehand placement if they do not participate * Additional CT or CBCT scans during the procedure.

Waitlist Available
Has No Placebo

UC San Diego (+2 Sites)

Sean Tutton, MD

Quantum Surgical

Image of University of Waterloo in Waterloo, Canada.

Virtual Chiropractic Intervention for Spinal Fracture

18+
All Sexes
Waterloo, Canada

This study will determine feasibility of a chiropractor delivered virtual intervention for individuals following osteoporotic vertebral fracture. This pilot trial will have two parallel groups with a 1:1 ratio. Participants will be randomized to: 1) immediate receipt; or 2) waitlist usual care control and delayed receipt of VIVA 10 weeks post-randomization. VIVA is an intervention for people with vertebral fractures that covers four areas: pain management, safe movement, exercise, and nutrition. It includes print and video resources, and a framework for goal setting, selecting exercises, and teaching body mechanics. A chiropractor (DC) completes a virtual assessment and then leads twelve 1:1 virtual sessions (via Zoom) over eight weeks. Sessions start with brief education on a topic (e.g., safe movement, pain management, exercise, nutrition), followed by training and modeling of exercise and safe movement strategies, then goal setting, and action planning. This trial will be considered feasible if a) we recruit 14 people in eight months; b) 80% of participants complete the trial; and c) exercise adherence is 75%.

Recruiting
Has No Placebo

University of Waterloo

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Image of Noll Laboratory in University Park, United States.

Estradiol and Elagolix for Menopause

42 - 64
Female
University Park, PA

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Phase 4
Recruiting

Noll Laboratory

W. Larry Kenney, Ph.D.

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