Zoloft

Bulimia Nervosa, Panic Disorder, Social Anxiety Disorder + 5 more
Treatment
10 FDA approvals
20 Active Studies for Zoloft

What is Zoloft

SertralineThe Generic name of this drug
Treatment SummarySertraline is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It works in a similar way to other SSRI drugs, such as Citalopram and Fluoxetine. It may take several weeks to start working and has fewer side effects than other types of antidepressant medications, such as drowsiness, dizziness, blurred vision, etc.
Sertraline Hydrochlorideis the brand name
image of different drug pills on a surface
Zoloft Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sertraline Hydrochloride
Sertraline
1992
502

Approved as Treatment by the FDA

Sertraline, also known as Sertraline Hydrochloride, is approved by the FDA for 10 uses like Obsessive Compulsive Disorder (OCD) and Social Anxiety Disorder (SAD) .
Obsessive Compulsive Disorder (OCD)
Social Anxiety Disorder (SAD)
Post Traumatic Stress Disorder (PTSD)
Panic Disorder
Premenstrual Dysphoric Disorder (PMDD)
Social Anxiety Disorder
Depression
Post Traumatic Stress Disorder
Panic Disorder
Obsessive-Compulsive Disorder

Effectiveness

How Zoloft Affects PatientsSertraline is used to treat depression, OCD, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder by blocking the reabsorption of serotonin in the brain. Studies have found that it can help with mental clarity for those with depression. It does not have as strong of sedative, anticholinergic, or cardiovascular effects as other types of antidepressants. Generally, patients will start to feel the benefits after 4-6 weeks, although the reasons for this are not yet fully understood.
How Zoloft works in the bodySertraline works by blocking the reuptake of serotonin in the brain, which increases the amount of serotonin in the brain. This is thought to be what causes its antidepressant and anti-anxiety effects. In animal studies, it also seems to reduce the number of norepinephrine receptors. Sertraline does not interact with GABA, dopamine, or benzodiazepine receptors, but does have a weak interaction with norepinephrine and dopamine receptors. It also does not inhibit the action of the monoamine oxidase enzyme.

When to interrupt dosage

The proposed measure of Zoloft is contingent upon the diagnosed circumstance, including Social Anxiety Disorder, Obsessive-Compulsive Disorder and Post Traumatic Stress Disorder. The measure of dosage shifts, in accordance with the administration technique (e.g. Tablet, film coated or Concentrate) laid out in the table beneath.
Condition
Dosage
Administration
Bulimia Nervosa
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Panic Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Social Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Obsessive-Compulsive Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Generalized Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Depression
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Post Traumatic Stress Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Binge-Eating Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral

Warnings

Zoloft has five established contraindications. Therefore, it should not be taken conjointly with any of the conditions in the table below.Zoloft Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Sertraline may interact with Pulse Frequency
There are 20 known major drug interactions with Zoloft.
Common Zoloft Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of serotonin syndrome can be increased when Sertraline is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Sertraline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Sertraline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Sertraline.
Azelastine
Major
Sertraline may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Zoloft Toxicity & Overdose RiskThe lowest toxic dose of sertraline in rats is greater than 2000mg/kg according to the FDA. Common side effects of an overdose may include sleepiness, vomiting, rapid heartbeat, nausea, dizziness, restlessness, and shaking. Fatal overdoses involving sertraline alone are rare, but may be more likely when taken with other drugs. Serious conditions that can arise from an overdose on sertraline include serotonin syndrome, high or low blood pressure, fainting, stupor, coma, slow heartbeat, irregular heartbeats, confusion, and pancreatitis.
image of a doctor in a lab doing drug, clinical research

Zoloft Novel Uses: Which Conditions Have a Clinical Trial Featuring Zoloft?

Presently, 526 active clinical trials are underway to investigate the potential of Zoloft to alleviate Bulimia Nervosa, Premenstrual Dysphoric Disorder and Obsessive-Compulsive Disorder.
Condition
Clinical Trials
Trial Phases
Post Traumatic Stress Disorder
281 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Generalized Anxiety Disorder
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Obsessive-Compulsive Disorder
18 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Panic Disorder
12 Actively Recruiting
Not Applicable, Phase 2
Bulimia Nervosa
0 Actively Recruiting
Social Anxiety Disorder
20 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Depression
187 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Binge-Eating Disorder
1 Actively Recruiting
Not Applicable

Zoloft Reviews: What are patients saying about Zoloft?

5Patient Review
8/22/2022
Zoloft for Panic Disorder
This treatment really improved my quality of life. I was struggling with panic attacks and anxiety, but this medication helped me to overcome those hurdles.
5Patient Review
9/7/2022
Zoloft for Repeated Episodes of Anxiety
Zoloft has been an incredible help for my anxiety and depression. It only took two weeks for the side effects to wear off, and they were entirely tolerable. I actually miss the crazy dreams I had while taking it.
5Patient Review
10/26/2022
Zoloft for Repeated Episodes of Anxiety
It helped me understand and prevent my anxiety. I had been stuck in a maze for so long, and this treatment allowed me to see above it.
5Patient Review
11/8/2022
Zoloft for Panic Disorder
I was really amazed by how well this medication worked with no side effects for me. It took away all my anxiety and racing thoughts. I don't have nearly as many panic attacks now, and they're not as bad when I do have them.
3Patient Review
7/28/2022
Zoloft for Major Depressive Disorder
This treatment was helpful for a week and then stopped being effective.
2.7Patient Review
8/30/2022
Zoloft for Panic Disorder
I was really hoping this would work, and it did for a few days until I had an allergic reaction. If you're not allergic, then I say give it a try.
2.3Patient Review
10/14/2022
Zoloft for Posttraumatic Stress Syndrome
I didn't feel any effects while taking this medication, even after six months. And it's only been three years since I stopped taking it, but I don't remember much from that time period.
2.3Patient Review
11/6/2022
Zoloft for Depression
At first, this medication made me feel pretty good. But eventually it stopped working and made things 10 times worse. I was hospitalized because of the increase in irritability, suicidal ideation, and other problems. Would not recommend to anyone.
1Patient Review
8/15/2022
Zoloft for Depression
This medication was absolutely terrible. I experienced night sweats, paranoia, hallucinations, diarrhea, nausea, vomiting and panic attacks. This medication should be banned!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zoloft

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Zoloft do for anxiety?

"Zoloft is an antidepressant that is also known as a selective serotonin reuptake inhibitor, or SSRI. This type of medication works by slowing down the reabsorption of serotonin."

Answered by AI

How does Zoloft make you feel?

"When used as prescribed, Zoloft can help reduce anxiety and fear, as well as the compulsive urge to perform certain tasks. Additionally, it can improve sleep quality, appetite, and energy levels, and help people who are experiencing intrusive thoughts and panic attacks feel more interested in day-to-day life."

Answered by AI

What are the side effects of Zoloft?

"If you experience any of the following side effects, you should contact your doctor immediately: headache, nausea, diarrhea, dry mouth, increased sweating, feeling nervous, restless, fatigued, sleepy, or having trouble sleeping (insomnia)."

Answered by AI

Is Zoloft a strong medicine?

"Prozac is a selective serotonin reuptake inhibitor (SSRI) and Zoloft is a selective serotonin reuptake inhibitor (SSRI).

Zoloft is a prescription medication used to treat depression and other issues. It is a brand-name drug and is a selective serotonin reuptake inhibitor (SSRI)."

Answered by AI

Clinical Trials for Zoloft

Have you considered Zoloft clinical trials? We made a collection of clinical trials featuring Zoloft, we think they might fit your search criteria.
Have you considered Zoloft clinical trials? We made a collection of clinical trials featuring Zoloft, we think they might fit your search criteria.
Have you considered Zoloft clinical trials? We made a collection of clinical trials featuring Zoloft, we think they might fit your search criteria.
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Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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