Your session is about to expire
What is Lokelma
Sodium zirconium cyclosilicateThe Generic name of this drug
Treatment SummaryLokelma is a medication used to reduce potassium levels in the blood. It is a powder that is mixed with water and taken orally, and has no taste or smell. Studies have shown that it starts working within 1 hour and usually gets potassium levels back to normal within 2.2 hours, with 92% of patients reaching normal levels within 48 hours. The effects can last for up to 12 months.
Lokelmais the brand name
Lokelma Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lokelma
Sodium zirconium cyclosilicate
2018
2
Effectiveness
How Lokelma Affects PatientsSodium zirconium cyclosilicate is a drug that helps lower potassium levels in the blood. It usually takes 1-2 days for the drug to take effect. It does not affect calcium, magnesium, or sodium levels. Taking the drug causes less potassium to be released in urine and more to be released in feces. It also increases the amount of bicarbonate and reduces the amount of aldosterone in the body. There have also been changes in blood urea nitrogen levels, but no changes in blood pressure.
How Lokelma works in the bodyHyperkalemia is a condition where there are too many potassium ions in the blood. It is common in people with kidney or heart failure. Sodium zirconium cyclosilicate works by trapping potassium ions in the stomach and intestines and then releasing them in the feces. This decreases the amount of free potassium in the body and helps lower high potassium levels in the blood.
When to interrupt dosage
The recommended dosage of Lokelma is contingent upon the identified affliction. The measure will differ as per the administration approach featured in the table beneath.Condition
Dosage
Administration
Hyperkalemia
1.0 mg/mg, 5.0 mg/mg, , 10000.0 mg, 5000.0 mg
Powder, for suspension - Oral, Powder, for suspension, Oral,
Warnings
There are 20 known major drug interactions with Lokelma.Common Lokelma Drug Interactions
Drug Name
Risk Level
Description
Atazanavir
Major
Sodium zirconium cyclosilicate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Sodium zirconium cyclosilicate.
Methenamine
Major
The therapeutic efficacy of Methenamine can be decreased when used in combination with Sodium zirconium cyclosilicate.
Bisacodyl
Minor
The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Sodium zirconium cyclosilicate.
Dabigatran etexilate
Minor
Sodium zirconium cyclosilicate can cause a decrease in the absorption of Dabigatran etexilate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lokelma Toxicity & Overdose RiskToo much sodium zirconium cyclosilicate could result in low potassium levels in the blood.
Lokelma Novel Uses: Which Conditions Have a Clinical Trial Featuring Lokelma?
At present, there are 7 active trials evaluating the potential of Lokelma to manage Hyperkalemia.Condition
Clinical Trials
Trial Phases
Hyperkalemia
5 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1
Lokelma Reviews: What are patients saying about Lokelma?
4Patient Review
2/15/2020 This powder mixes well with water and is very effective at relieving constipation. However, the copay is quite high.
Patient Q&A Section about lokelma
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How does Lokelma lower potassium?
"LOKELMA works by binding potassium in the gastrointestinal tract, which reduces the amount of free potassium in the gut and helps to lower serum potassium levels."
Answered by AI
How fast does Lokelma lower potassium?
"LOKELMA begins lowering your potassium level within one hour of taking it. The extent of the decrease depends on your starting potassium level. Most patients have normal potassium levels within 24 to 48 hours of treatment."
Answered by AI
Is Lokelma the same as Kayexalate?
"The FDA approved oral sodium zirconium cyclosilicate (ZS-9), to be marketed as Lokelma, for the treatment of hyperkalemia. The drug reduces serum potassium levels within an hour and restoring normal levels after about 2 hours in most patients, which is better than sodium polystyrene sulfonate (Kayexalate)."
Answered by AI
What is the medication Lokelma used for?
"This medication is used to treat high levels of potassium in the blood. It works by binding to potassium in the gut and preventing it from being absorbed into the blood. This medication does not work immediately, and should not be used to treat potentially life-threatening high levels of potassium."
Answered by AI