Timolol Maleate

Migraine, Open-angle glaucoma, Migraine Disorders + 6 more
Treatment
20 Active Studies for Timolol Maleate

What is Timolol Maleate

TimololThe Generic name of this drug
Treatment SummaryDorzolamide is an eye medication used to lower the pressure in the eyes of people with glaucoma or ocular hypertension. It works by blocking an enzyme in the ciliary process, which regulates the balance of ions and fluids in the eyes. Unlike other medications that treat eye pressure, dorzolamide does not cause acid-base or electrolyte disturbances or any other systemic side effects. It was first approved by the FDA in 1995 and is available as a single medication (Trusopt) or in combination with timolol (Cosopt PF).
Timopticis the brand name
image of different drug pills on a surface
Timolol Maleate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Timoptic
Timolol
1978
167

Effectiveness

How Timolol Maleate Affects PatientsDorzolamide is a medication used to treat open-angle glaucoma or ocular hypertension. It works by lowering the pressure in the eye, with the maximum effect seen about two hours after it is taken. When used with other medications, the effects of dorzolamide are stronger and can lower eye pressure even more.
How Timolol Maleate works in the bodyDorzolamide is a medication used to treat ocular hypertension or glaucoma. It works by decreasing the production of aqueous humor, a fluid in the eye, which reduces the intraocular pressure. It does this by blocking an enzyme called carbonic anhydrase II, which helps with the production of bicarbonate ions. By blocking this enzyme, sodium and fluid transport is disrupted and aqueous humor secretion is reduced, resulting in a decrease in intraocular pressure.

When to interrupt dosage

Condition
Dosage
Administration
Migraine Disorders
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Open-angle glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Migraine
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
inadequate response to other therapeutic measures
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
insufficient response to beta-blockers
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
requiring adjunctive or replacement therapy
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Open Angle Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Ocular Hypertension
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops

Warnings

Timolol Maleate has one contraindication and should not be blended with the ailments presented in the following table.Timolol Maleate Contraindications
Condition
Risk Level
Notes
Lung Diseases, Obstructive
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Atrioventricular Block
Do Not Combine
Asthma
Do Not Combine
Heart Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Timolol may interact with Pulse Frequency
There are 20 known major drug interactions with Timolol Maleate.
Common Timolol Maleate Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Timolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Timolol.
Abediterol
Major
Timolol may decrease the bronchodilatory activities of Abediterol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Timolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Timolol.
Timolol Maleate Toxicity & Overdose RiskThe lowest toxic dose of dorzolamide in rats is 1927mg/kg and in mice is 1320 mg/kg. An overdose may lead to electrolyte imbalance, acidosis, or effects on the central nervous system. To address these symptoms, supportive care should be provided and the patient's potassium levels and blood pH levels should be monitored.
image of a doctor in a lab doing drug, clinical research

Timolol Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Timolol Maleate?

Currently, 34 active clinical trials are being conducted to investigate the effectiveness of Timolol Maleate in tackling Ocular Hypertension, Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma.
Condition
Clinical Trials
Trial Phases
Open-angle glaucoma
45 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1
Open Angle Glaucoma
10 Actively Recruiting
Phase 3, Not Applicable, Phase 4
Ocular Hypertension
10 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
requiring adjunctive or replacement therapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Migraine
51 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1
Glaucoma
0 Actively Recruiting
insufficient response to beta-blockers
0 Actively Recruiting

Timolol Maleate Reviews: What are patients saying about Timolol Maleate?

4.7Patient Review
2/16/2011
Timolol Maleate for Wide-Angle Glaucoma
This medication was successful in keeping the pressure in my eyes normal.
4Patient Review
10/28/2008
Timolol Maleate for Increased Pressure in the Eye
This medication is easy to use and seems to be effective. I get the generic version which is much less expensive than other medications I've tried.
4Patient Review
6/12/2010
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
This is the third drop my doctor has tried and this one seems to be helping a little bit. It's easy to use and doesn't make me dizzy like Alphagan did.
4Patient Review
6/28/2014
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
This drug has been successful in reducing the pressure in my eyes. However, I have also noticed that my hair has been thinning out recently. Could this be a side effect of the medication?
4Patient Review
10/27/2010
Timolol Maleate for Increased Pressure in the Eye
The container is a little tough to use, but the drops work well and have few side effects.
4Patient Review
1/15/2014
Timolol Maleate for Wide-Angle Glaucoma
This medication seems to be effective at maintaining a healthy blood pressure.
3.7Patient Review
2/4/2017
Timolol Maleate for Wide-Angle Glaucoma
The last two prescriptions of Timolol have had a different base ingredient which causes a sticky substance to deal with every morning. My eyelashes are stuck together, which is very inconvenient. Why the change?
3.7Patient Review
6/6/2012
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
I've been taking this medication for about 16 years now, ever since I was first diagnosed. I have noticed that it seems to contribute to my bouts of depression, as well as heart palpitations.
3.3Patient Review
2/28/2017
Timolol Maleate for Closed Angle Glaucoma
This treatment has been effective in reducing my blood pressure; however, I have developed large red blotches on my face that are unsightly and painful.
3.3Patient Review
1/26/2012
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
I have noticed some problems with dizziness since starting this medication.
2.3Patient Review
10/3/2022
Timolol Maleate for Wide-Angle Glaucoma
I have been taking Timolol for a while now to treat my open angle glaucoma, but I have found that it has caused my hair to fall out and made me dizzy. I have tried telling this to my eye consultant, but they don't seem to be taking me seriously. So, I've decided to stop taking Timolol and stick with Latanoprost. I'm also going to try taking Ginkgo Bilbo capsules with dinner to see if that helps. It's all a matter of trial and error at this point.
2.3Patient Review
7/16/2011
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
At first, this lowered my blood pressure. But then it stopped working as well and started giving me drowsy side effects, as well as a lower libido.
2.3Patient Review
2/27/2019
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
I experienced a significant drop in blood pressure (worst reading was 102/53) after taking this medication, which made me feel extremely tired--which is very unusual for me.
2Patient Review
2/20/2016
Timolol Maleate for Closed Angle Glaucoma
Timilol hardens quickly and creates a glue-like consistency that is very difficult to remove. I have to use tissues and warm water to try and soften it, but by morning my lashes are stuck together.
2Patient Review
6/16/2009
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
After starting my cat on this medication, they began vomiting within 20 minutes. Three times. Is this a common reaction in cats?
1.7Patient Review
7/12/2011
Timolol Maleate for Increased Pressure in the Eye
I experienced redness and crusting around my eyelids.
1Patient Review
3/30/2018
Timolol Maleate for Wide-Angle Glaucoma
After just two weeks of using this eye drop in conjunction with latanoprost, I constantly felt cold, tired, and on the verge of tears. My sex drive disappeared and I had difficulty sleeping or staying asleep due to anxious dreams. I would have rather been blind than continue living like that. Thankfully, after stopping the timolol, these side effects lessened and eventually disappeared over the course of four weeks.
1Patient Review
5/17/2018
Timolol Maleate for High Eye Pressure or Glaucoma that May Worsen without Treatment
Unfortunately, this drug caused my heart rate to drop 10 points. I'm glad that I have been monitoring my blood pressure and heart rate for years because it helped me relate the drop in heart rate to the eye drops.

Patient Q&A Section about timolol maleate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long should timolol eye drops be used?

"Ophthalmic timolol is a solution that comes in liquid form, as well as an extended-release gel-forming solution. The latter thickens to a gel when instilled in the eye. Timolol eye drops are usually instilled once or twice a day, at evenly spaced intervals, until pressure in the eye is controlled (about 4 weeks)."

Answered by AI

What is the side effects of timolol maleate?

"If you experience any of the following effects for more than a short period of time, you should tell your doctor or pharmacist. These include temporary blurred vision, burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, or headache."

Answered by AI

What is timolol maleate used for?

"This medication is used to treat high pressure in the eye that is caused by open-angle glaucoma or a condition called ocular hypertension. This medicine is a beta blocker."

Answered by AI

What is the difference between timolol and timolol maleate?

"28 healthy subjects were given either timolol hemihydrate or timolol maleate in both eyes twice a day for a week, in a double masked fashion. The only known difference between the two preparations is the maleate salt."

Answered by AI

Clinical Trials for Timolol Maleate

Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.
Waitlist Available
Has No Placebo
Johns Hopkins MedicineRisheng Xu, MD, PhDMedtronic
Have you considered Timolol Maleate clinical trials? We made a collection of clinical trials featuring Timolol Maleate, we think they might fit your search criteria.Go to Trials
Have you considered Timolol Maleate clinical trials? We made a collection of clinical trials featuring Timolol Maleate, we think they might fit your search criteria.Go to Trials
Image of Mount Sinai Hospital in New York, United States.

Rimegepant + Zavegepant for Migraine

18+
All Sexes
New York, NY
This study evaluates the effectiveness of rimegepant 75 mg orally disintegrating tablet (ODT) single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments during Emergency Department (ED) encounters. Although these two calcitonin gene-related peptide receptors (CGRP) receptor antagonists are FDA-approved for the indication of acute migraine treatment, past studies have been limited to the outpatient setting. If these medications are effective in the Emergency Department, their delivery methods alone may have advantages over intravenous medications commonly used for acute migraine in EDs, including quicker time to treatment delivery, faster pain relief, and reduced ED length of stay. This investigation is a pilot study to examine rimegepant and zavegepant in an ED, to gain insight on effectiveness in this setting. This study will administer rimegepant 75 mg ODT single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments to 100 patients in the Emergency Department. It is a single center, open-label, non-controlled 2-group clinical trial (allocated 1:1 to rimegepant or zavegepant via pseudo-random assignment). The study will enroll adults in the ED meeting ICHD-3 criteria for migraine or probable migraine, with or without aura.
Phase 4
Recruiting
Mount Sinai HospitalJonathan SchimmelPfizer
Have you considered Timolol Maleate clinical trials? We made a collection of clinical trials featuring Timolol Maleate, we think they might fit your search criteria.Go to Trials
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