Tolazamide

Type 2 Diabetes
Treatment
2 FDA approvals
20 Active Studies for Tolazamide

What is Tolazamide

TolazamideThe Generic name of this drug
Treatment SummaryGlipizide is a medication used to lower blood sugar levels in people with diabetes. It works similarly to the diabetes medication chlorpropamide.
Tolazamideis the brand name
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Tolazamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tolazamide
Tolazamide
1995
11

Approved as Treatment by the FDA

Tolazamide, otherwise called Tolazamide, is approved by the FDA for 2 uses like Type 2 Diabetes Mellitus and Type 2 Diabetes .
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus

Effectiveness

How Tolazamide Affects PatientsTolazamide is a type of medication that helps to lower blood sugar levels. It does this by stimulating the pancreas to release insulin. This effect usually lessens over time, so sometimes other medications may need to be used. Tolazamide may also be effective for people who have become unresponsive to other drugs in the same class. On top of lowering blood sugar levels, it also helps the body get rid of extra water.
How Tolazamide works in the bodySulfonylureas help your pancreas release insulin. They do this by blocking the flow of potassium in and out of the cells. This causes the cells to become more electrically charged, triggering an influx of calcium ions. The calcium ions signal the release of insulin from the pancreas.

When to interrupt dosage

The suggested dosage of Tolazamide is contingent upon the determined condition. The quantity of dosage changes in accordance with the technique of delivery (e.g. Oral or Tablet - Oral) listed in the table below.
Condition
Dosage
Administration
Type 2 Diabetes
250.0 mg, , 500.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Tolazamide Contraindications
Condition
Risk Level
Notes
Diabetes Mellitus, Type 1
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
There are 20 known major drug interactions with Tolazamide.
Common Tolazamide Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
Tolazamide may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Minor
Tolazamide may increase the anticoagulant activities of (S)-Warfarin.
Abacavir
Minor
Tolazamide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Tolazamide.
Aclidinium
Minor
Tolazamide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Tolazamide Toxicity & Overdose RiskTaking too much of a sulfonylurea drug can result in dangerously low blood sugar levels, which can cause dizziness, confusion, seizures, and even loss of consciousness. These symptoms require urgent medical attention.
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Tolazamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Tolazamide?

162 active clinical trials are currently being conducted to investigate the potential of Tolazamide to manage Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
167 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Tolazamide Reviews: What are patients saying about Tolazamide?

2.7Patient Review
4/5/2018
Tolazamide for Type 2 Diabetes Mellitus
Beware of long-term use of this medication. I nearly died as a result of liver failure after taking it for several months. The doctors determined that the diabetes medication Tolazamide was to blame. Please consult with your doctor and do your research before starting any new medications.
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Patient Q&A Section about tolazamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Tolazamide available in the USA?

"Tolazamide is no longer available in the United States as of September 15, 2020."

Answered by AI

Which ring is present in Tolazamide?

"Tolazamide is one type of N-sulfonylurea that is 1-tosylurea in which the nitrogen at position 3 has an azepan-1-yl group instead of a hydrogen atom. It is used as a hypoglycemic agent to treat type 2 diabetes mellitus."

Answered by AI

What is Tolazamide used for?

"Tolazamide is used to treat high blood sugar levels caused by type 2 diabetes mellitus. Type 2 diabetes is a condition in which your body does not work properly to store excess sugar and the sugar remains in your bloodstream."

Answered by AI

What is the brand name of Tolazamide?

"TOLINASE tablets can be used as a complement to diet to help lower blood sugar in patients with non-insulin dependent diabetes mellitus (Type II) who cannot adequately control their hyperglycemia with diet alone."

Answered by AI

Clinical Trials for Tolazamide

Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
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PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
Have you considered Tolazamide clinical trials? We made a collection of clinical trials featuring Tolazamide, we think they might fit your search criteria.Go to Trials
Have you considered Tolazamide clinical trials? We made a collection of clinical trials featuring Tolazamide, we think they might fit your search criteria.Go to Trials
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Continuous vs Finger-stick Glucose Monitoring for Type 2 Diabetes in Pregnancy

18+
Female
Sewell, NJ
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM). Pregnant patients with T2DM are at risk of having larger babies, babies with low sugar levels in the first 24 hours of life, higher rates of cesarean delivery, stillbirth (death of baby inside the womb), and hypertensive or high blood pressure disorders of pregnancy, such as preeclampsia. Prior studies have shown that treating high blood sugars in pregnancy with medications can reduce these risks. To determine the amount of medication needed, recording of blood sugar levels is necessary. This trial aims to determine whether continuous blood sugar monitors have improved patient recording of blood sugar levels over finger stick blood sugar measurements. Patients involved in the study will be assigned to either: 1. Fingerstick glucose monitoring (FSG) 2. Continuous glucose monitoring (CGM) Patients will be randomize in a 1:1 ratio. FSG Group: blood sugar is tested four times daily - once fasting and two hours after every meal (post-prandial). Blood will be tested using a glucometer, and values will be recorded in a blood sugar log from the time of enrollment to the time of delivery. CGM Group: A CGM sensor will be placed on the patient's arm for blood sugar collection every 3-5 minutes. This data is sent to a phone application from the time of enrollment to the time of delivery. These sensors will need to be replaced every 14 days. Percent adherence will be recorded from the time you were randomized to a study group until delivery.
Recruiting
Has No Placebo
Jefferson Health New Jersey (+1 Sites)
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Health Coaching for Type 2 Diabetes and Mental Health

18+
All Sexes
Hamilton, Canada
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both. This study looks at how virtual health coaching and support from interdisciplinary care teams can help people better manage their health. The purpose of this study is to test the effectiveness of a virtual health coaching program for adults living with type 2 diabetes and mental health challenges compared to usual care. The Technology-Enabled Collaborative Care for type 2 Diabetes and Mental health (TECC-DM) program includes weekly coaching calls, support from an interdisciplinary care team, and online tools to aid self-management. The findings from this study will be used to help improve services for people who have type 2 diabetes and co-occurring mental health symptoms.
Waitlist Available
Has No Placebo
McMaster UniversityCarly Whitmore, RN PhD
Have you considered Tolazamide clinical trials? We made a collection of clinical trials featuring Tolazamide, we think they might fit your search criteria.Go to Trials
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