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What is Tricor
FenofibrateThe Generic name of this drug
Treatment SummaryFenofibrate is a medication used to treat high cholesterol, high triglycerides, and other related lipid disorders. It belongs to a class of medications called fibric acid derivatives, which also includes clofibrate and gemfibrozil. Fenofibrate was approved by the FDA in 1993 and is often prescribed to reduce cholesterol and triglyceride levels.
Tricoris the brand name
Tricor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tricor
Fenofibrate
2002
421
Approved as Treatment by the FDA
Fenofibrate, also known as Tricor, is approved by the FDA for 8 uses which include Hypertriglyceridemia and Severe Hypertriglyceridemia (sHTG) .Hypertriglyceridemia
Severe Hypertriglyceridemia (sHTG)
Primary Hypercholesterolemia
Hypertriglyceridemia
Hypertriglyceridemia
severe Fredrickson Type V Hypertriglyceridemia
severe Fredrickson Type IV Hypertriglyceridemia
Dyslipidemias
Effectiveness
How Tricor Affects PatientsFenofibrate is a type of drug used to treat high cholesterol, mixed fat levels, and severe high triglycerides in the blood. It is generally taken once per day and its effects can last between 19-27 hours. The drug is usually taken at a dose of 50-150mg daily and has a wide therapeutic index, meaning it is relatively safe. However, patients should be aware of the possible risks such as muscle breakdown, muscle pain, and gallstones.
How Tricor works in the bodyFenofibrate works by activating a receptor in your cells known as PPARα. This triggers the breakdown of fat, increases the activity of lipoprotein lipase, and reduces the amount of a certain protein. Activating PPARα also causes your cells to produce peroxisomes which contain hydrogen peroxide, oxygen molecules, and hydroxyl radicals which aid in fat breakdown. This increased fat metabolism can place stress on the liver, which in rare cases can lead to cirrhosis and chronic active hepatitis.
When to interrupt dosage
The quantity of Tricor is contingent upon the determined condition, such as severe Fredrickson Type V Hypertriglyceridemia, Dyslipidemias and Hypertriglyceridemia. The amount of dosage is contingent upon the technique of delivery (e.g. Oral or Tablet, film coated) specified in the following table.Condition
Dosage
Administration
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Primary Hypercholesterolemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Dyslipidemias
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Tricor has three contraindications and should not be taken if you experience any of the conditions in the below mentioned table.Tricor ContraindicationsCondition
Risk Level
Notes
Liver Diseases
Do Not Combine
Gallbladder Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibrate may interact with Pulse Frequency
Common Tricor Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fenofibrate.
Aluminium clofibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Aluminium clofibrate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fenofibrate.
Bezafibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Bezafibrate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fenofibrate.
Tricor Toxicity & Overdose RiskThe lowest toxic dose of fenofibrate in rats is greater than 2g/kg and 1600mg/kg in mice. If a patient has recently overdosed on fenofibrate, supportive care such as monitoring vital signs and observing their clinical status should be done. Inducing vomiting or gastric lavage may also help remove the drug from the body. Since fenofibrate binds to proteins, hemodialysis is not likely to be effective.
Tricor Novel Uses: Which Conditions Have a Clinical Trial Featuring Tricor?
Fifteen investigations are currently in progress to assess the potential of Tricor to alleviate severe Fredrickson Type V Hypertriglyceridemia, Hypertriglyceridemia and Dyslipidemias.Condition
Clinical Trials
Trial Phases
Primary Hypercholesterolemia
12 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hypertriglyceridemia
6 Actively Recruiting
Phase 3
Hypertriglyceridemia
0 Actively Recruiting
Hypertriglyceridemia
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2
Tricor Reviews: What are patients saying about Tricor?
5Patient Review
9/21/2015 I've been on Tricor for a long time now, and it has done wonders for my triglyceride levels. They were once over 500 but are now down to 100. The drug is highly effective with few to no side effects.
5Patient Review
3/4/2014 I was first prescribed Tricor in September 2013. I had been taking statins prior and stopped because I experienced muscle weakness each time; however, my new doctor put me on Tricor. Unfortunately, after only five days of taking the 145 mg pills, I could not raise myself off the toilet! My leg muscles just wouldn't cooperate. Thankfully, I stopped taking the pills immediately and my muscles returned to normal within a few days.
5Patient Review
3/26/20134.7Patient Review
5/15/2014 So far, so good.
4.3Patient Review
9/6/2015 My triglyceride levels stayed down while I was taking this medication; however, my new doctor took me off of it and now my levels have gone up again. I'm not sure what to do at this point.
4.3Patient Review
12/13/2018 This treatment was very effective in reducing my triglyceride levels. However, I did have some negative side effects like gall bladder removal and chronic aches and pains.
4Patient Review
7/24/2014 I wish I had known about the potential side effect of gallstones before taking this medication. I ended up having to have emergency surgery as a result of a huge gallstone that caused gangrene in my gallbladder. Thankfully, my doctor said that since I don't have a gallbladder anymore, this shouldn't be a problem. Changing my diet has also helped keep my triglyceride levels low for years. It's hard to know if it was "only" the drug or all of my lifestyle changes that made the difference, but either way, I'm glad I made the changes.
3.3Patient Review
6/27/2015 I recently realized that one of the side effects of this medication is gallbladder problems. I wonder if this is why I had agallbladder attack. The medication did reduce my triglyceride somewhat, but I don't know if it's worth the risk of developing gallbladder problems.
3Patient Review
8/6/2014 I'd been taking Tricor for years before I realized that it might be the cause of my numbness in fingers and joints, as well as the severe leg and arm cramps. So I stopped taking it today.
3Patient Review
3/7/20131.7Patient Review
7/20/2015 I took Tricor for a few years and occasionally experienced severe pain and bloating in my chest. I eventually turned green (no joke) from the bile duct blockage and had to have my gallbladder removed.
1Patient Review
1/15/2014 I've been experiencing some cognitive difficulties since starting this medication. I have trouble identifying objects, and sometimes I'll forget words. This makes reading and writing more difficult for me. Has anyone else experienced this?
1Patient Review
3/18/2014 I tried one pill on a stomach with food and it made me VERY ill, thought I'd have to call 9-11!!! My stomach and insides felt like they were on fire!! I sat up all night trying to get the fire put out in my stomach......this crap needs to be re-called!!! NEVER again!!
1Patient Review
6/2/2016 I only took a quarter of the pill because I know how sensitive I am to medication, and even that resulted in severe stomach pain, nausea, heavy bloating, fatigue, and orange urine. The pains in my hips and back were also very tearing and twisty.
1Patient Review
2/16/2014 I was really hoping this would help my chest pain, but unfortunately it didn't.
1Patient Review
4/17/2016 I had a terrible reaction to Tricor, only two weeks in. If you experience any itching or hives, go to the hospital right away! I'm still feeling the effects and it's been incredibly uncomfortable. Luckily I was able to stop taking the medicine, but now I'm struggling with chest and back pains.
1Patient Review
9/9/2016 I felt completely exhausted and weak after taking this medication, and I also felt nauseous.
Patient Q&A Section about tricor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects for TriCor?
"or change in the amount of urine
You might have a stomach ache, feel nauseous, and throw up. You might also have back pain, a headache, and a runny or stuffy nose. Your eyes and skin might be yellow, and you might pee less or more than usual."
Answered by AI
How does TriCor lower triglycerides?
"Fenofibrate belongs to a group of drugs known as "fibrates" that work by increasing the natural substance (enzyme) that breaks down fats in the blood. Lowering triglycerides in people with very high triglyceride blood levels may decrease the risk of pancreas disease (pancreatitis)."
Answered by AI
What type of drug is TriCor?
"Tricor is a prescription medicine that is used to help reduce symptoms related to cholesterol and triglycerides in the blood. It can be used alone or in combination with other medications. Tricor is classified as a Fibric Acid Agent."
Answered by AI
What is the drug TriCor used for?
"TriCor is a prescription medicine used in adults, either alone or with a diet, to lower triglycerides, total cholesterol, and LDL (bad) cholesterol, and to increase HDL (good) cholesterol. It is also used in adults with severely high triglycerides, again either alone or with a diet."
Answered by AI