Tricor

Hypertriglyceridemia, Hypertriglyceridemia, Primary Hypercholesterolemia + 2 more
Treatment
8 FDA approvals
15 Active Studies for Tricor

What is Tricor

FenofibrateThe Generic name of this drug
Treatment SummaryFenofibrate is a medication used to treat high cholesterol, high triglycerides, and other related lipid disorders. It belongs to a class of medications called fibric acid derivatives, which also includes clofibrate and gemfibrozil. Fenofibrate was approved by the FDA in 1993 and is often prescribed to reduce cholesterol and triglyceride levels.
Tricoris the brand name
Tricor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tricor
Fenofibrate
2002
421

Approved as Treatment by the FDA

Fenofibrate, also known as Tricor, is approved by the FDA for 8 uses which include Hypertriglyceridemia and Hypertriglyceridemia .
Hypertriglyceridemia
Hypertriglyceridemia
Hypertriglyceridemia
Primary Hypercholesterolemia
Severe Hypertriglyceridemia (sHTG)
severe Fredrickson Type V Hypertriglyceridemia
severe Fredrickson Type IV Hypertriglyceridemia
Dyslipidemias

Effectiveness

How Tricor Affects PatientsFenofibrate is a type of drug used to treat high cholesterol, mixed fat levels, and severe high triglycerides in the blood. It is generally taken once per day and its effects can last between 19-27 hours. The drug is usually taken at a dose of 50-150mg daily and has a wide therapeutic index, meaning it is relatively safe. However, patients should be aware of the possible risks such as muscle breakdown, muscle pain, and gallstones.
How Tricor works in the bodyFenofibrate works by activating a receptor in your cells known as PPARα. This triggers the breakdown of fat, increases the activity of lipoprotein lipase, and reduces the amount of a certain protein. Activating PPARα also causes your cells to produce peroxisomes which contain hydrogen peroxide, oxygen molecules, and hydroxyl radicals which aid in fat breakdown. This increased fat metabolism can place stress on the liver, which in rare cases can lead to cirrhosis and chronic active hepatitis.

When to interrupt dosage

The quantity of Tricor is contingent upon the determined condition, such as severe Fredrickson Type V Hypertriglyceridemia, Dyslipidemias and Hypertriglyceridemia. The amount of dosage is contingent upon the technique of delivery (e.g. Oral or Tablet, film coated) specified in the following table.
Condition
Dosage
Administration
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Primary Hypercholesterolemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Dyslipidemias
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Tricor has three contraindications and should not be taken if you experience any of the conditions in the below mentioned table.Tricor Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Gallbladder Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibrate may interact with Pulse Frequency
There are 20 known major drug interactions with Tricor.
Common Tricor Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fenofibrate.
Aluminium clofibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Aluminium clofibrate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fenofibrate.
Bezafibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Bezafibrate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fenofibrate.
Tricor Toxicity & Overdose RiskThe lowest toxic dose of fenofibrate in rats is greater than 2g/kg and 1600mg/kg in mice. If a patient has recently overdosed on fenofibrate, supportive care such as monitoring vital signs and observing their clinical status should be done. Inducing vomiting or gastric lavage may also help remove the drug from the body. Since fenofibrate binds to proteins, hemodialysis is not likely to be effective.
image of a doctor in a lab doing drug, clinical research

Tricor Novel Uses: Which Conditions Have a Clinical Trial Featuring Tricor?

Fifteen investigations are currently in progress to assess the potential of Tricor to alleviate severe Fredrickson Type V Hypertriglyceridemia, Hypertriglyceridemia and Dyslipidemias.
Condition
Clinical Trials
Trial Phases
Primary Hypercholesterolemia
8 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hypertriglyceridemia
5 Actively Recruiting
Phase 3
Hypertriglyceridemia
0 Actively Recruiting
Hypertriglyceridemia
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2

Tricor Reviews: What are patients saying about Tricor?

5Patient Review
9/21/2015
Tricor for Combined High Blood Cholesterol and Triglyceride Level
I've been on Tricor for a long time now, and it has done wonders for my triglyceride levels. They were once over 500 but are now down to 100. The drug is highly effective with few to no side effects.
5Patient Review
3/4/2014
Tricor for High Amount of Triglyceride in the Blood
I was first prescribed Tricor in September 2013. I had been taking statins prior and stopped because I experienced muscle weakness each time; however, my new doctor put me on Tricor. Unfortunately, after only five days of taking the 145 mg pills, I could not raise myself off the toilet! My leg muscles just wouldn't cooperate. Thankfully, I stopped taking the pills immediately and my muscles returned to normal within a few days.
5Patient Review
3/26/2013
Tricor for High Amount of Triglyceride in the Blood
4.7Patient Review
5/15/2014
Tricor for High Cholesterol
So far, so good.
4.3Patient Review
9/6/2015
Tricor for High Amount of Triglyceride in the Blood
My triglyceride levels stayed down while I was taking this medication; however, my new doctor took me off of it and now my levels have gone up again. I'm not sure what to do at this point.
4.3Patient Review
12/13/2018
Tricor for High Amount of Triglyceride in the Blood
This treatment was very effective in reducing my triglyceride levels. However, I did have some negative side effects like gall bladder removal and chronic aches and pains.
4Patient Review
7/24/2014
Tricor for High Amount of Triglyceride in the Blood
I wish I had known about the potential side effect of gallstones before taking this medication. I ended up having to have emergency surgery as a result of a huge gallstone that caused gangrene in my gallbladder. Thankfully, my doctor said that since I don't have a gallbladder anymore, this shouldn't be a problem. Changing my diet has also helped keep my triglyceride levels low for years. It's hard to know if it was "only" the drug or all of my lifestyle changes that made the difference, but either way, I'm glad I made the changes.
3.3Patient Review
6/27/2015
Tricor for High Amount of Triglyceride in the Blood
I recently realized that one of the side effects of this medication is gallbladder problems. I wonder if this is why I had agallbladder attack. The medication did reduce my triglyceride somewhat, but I don't know if it's worth the risk of developing gallbladder problems.
3Patient Review
8/6/2014
Tricor for High Amount of Triglyceride in the Blood
I'd been taking Tricor for years before I realized that it might be the cause of my numbness in fingers and joints, as well as the severe leg and arm cramps. So I stopped taking it today.
3Patient Review
3/7/2013
Tricor for High Amount of Triglyceride in the Blood
1.7Patient Review
7/20/2015
Tricor for Combined High Blood Cholesterol and Triglyceride Level
I took Tricor for a few years and occasionally experienced severe pain and bloating in my chest. I eventually turned green (no joke) from the bile duct blockage and had to have my gallbladder removed.
1Patient Review
1/15/2014
Tricor for High Cholesterol
I've been experiencing some cognitive difficulties since starting this medication. I have trouble identifying objects, and sometimes I'll forget words. This makes reading and writing more difficult for me. Has anyone else experienced this?
1Patient Review
3/18/2014
Tricor for Combined High Blood Cholesterol and Triglyceride Level
I tried one pill on a stomach with food and it made me VERY ill, thought I'd have to call 9-11!!! My stomach and insides felt like they were on fire!! I sat up all night trying to get the fire put out in my stomach......this crap needs to be re-called!!! NEVER again!!
1Patient Review
6/2/2016
Tricor for High Cholesterol
I only took a quarter of the pill because I know how sensitive I am to medication, and even that resulted in severe stomach pain, nausea, heavy bloating, fatigue, and orange urine. The pains in my hips and back were also very tearing and twisty.
1Patient Review
2/16/2014
Tricor for Combined High Blood Cholesterol and Triglyceride Level
I was really hoping this would help my chest pain, but unfortunately it didn't.
1Patient Review
4/17/2016
Tricor for High Amount of Triglyceride in the Blood
I had a terrible reaction to Tricor, only two weeks in. If you experience any itching or hives, go to the hospital right away! I'm still feeling the effects and it's been incredibly uncomfortable. Luckily I was able to stop taking the medicine, but now I'm struggling with chest and back pains.
1Patient Review
9/9/2016
Tricor for High Amount of Triglyceride in the Blood
I felt completely exhausted and weak after taking this medication, and I also felt nauseous.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tricor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects for TriCor?

"or change in the amount of urine

You might have a stomach ache, feel nauseous, and throw up. You might also have back pain, a headache, and a runny or stuffy nose. Your eyes and skin might be yellow, and you might pee less or more than usual."

Answered by AI

How does TriCor lower triglycerides?

"Fenofibrate belongs to a group of drugs known as "fibrates" that work by increasing the natural substance (enzyme) that breaks down fats in the blood. Lowering triglycerides in people with very high triglyceride blood levels may decrease the risk of pancreas disease (pancreatitis)."

Answered by AI

What type of drug is TriCor?

"Tricor is a prescription medicine that is used to help reduce symptoms related to cholesterol and triglycerides in the blood. It can be used alone or in combination with other medications. Tricor is classified as a Fibric Acid Agent."

Answered by AI

What is the drug TriCor used for?

"TriCor is a prescription medicine used in adults, either alone or with a diet, to lower triglycerides, total cholesterol, and LDL (bad) cholesterol, and to increase HDL (good) cholesterol. It is also used in adults with severely high triglycerides, again either alone or with a diet."

Answered by AI

Clinical Trials for Tricor

Image of Clinical Research Site 4 in Santa Clarita, United States.

Plozasiran for Hypertriglyceridemia

18+
All Sexes
Santa Clarita, CA
This study will evaluate the efficacy and safety of plozasiran in approximately 288 adult participants with severe hypertriglyceridemia (SHTG) and history of at least two prior acute pancreatitis (AP) events not attributed to other etiologies, with at least one occurring within the last 12 months prior to screening. Eligible participants will be randomly assigned in a double-blind manner to either receive plozasiran 25 mg by subcutaneous (SC) injection every three months (Q3M) or matching placebo. Enrolled participants will be counseled to remain on the specified low-fat diet and background medications throughout the study. Following completion of the double-blind treatment period, or if the participant has a positively adjudicated AP event (whichever occurs first), participants will transition to the 12-month Open-Label Extension (OLE) treatment period receiving plozasiran 25 mg by SC injection Q3M.
Phase 3
Recruiting
Clinical Research Site 4 (+9 Sites)Arrowhead Pharmaceuticals
Image of Atlantic Medical Group in Clark, United States.

Supportive Care for High Cholesterol

18 - 120
All Sexes
Clark, NJ
Hypercholesterolemia is recognized as the major driver for cardiovascular morbidity and mortality. To help address this in our community, Atlantic Medical Group (AMG) formed a lipid workgroup chaired by Robert D. Fishberg, MD, and Jeffrey N. Feldman, MD. The overarching goal of the lipid workgroup is to enhance the treatment of lipid disorders in those patients with abnormal lipid levels by improving access to resources at the primary care practice level and specialty level. We aim to develop a model for primary and secondary prevention that integrates guidelines for treatment at the practice level. Our primary objective is to identify high-risk patients by utilizing the electronic health record and partnering with patients' primary care providers to provide comprehensive medical management.
Recruiting
Has No Placebo
Atlantic Medical Group (+1 Sites)Robert D Fishberg, MDRegeneron Pharmaceuticals
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Image of University of Pennsylvania, Perelman School of Medicine in Philadelphia, United States.

Cascade Screening for High Cholesterol

18+
All Sexes
Philadelphia, PA
The goal of this clinical trial is to test two implementation strategies (automated health system \[Penn Medicine\]-mediated strategy vs. Family Heart Foundation-mediated strategy using a patient navigator) versus usual care to promote family cascade screening for familial hypercholesterolemia (FH) in Penn Medicine patients diagnosed with FH ("probands"). The main questions this study aims to answer are: (1) evaluating the effect of the three approaches on reach (proportion of probands who have at least one family member who completes screening), number of family members screened, number of family members diagnosed with FH, and proband LDL-C levels; and (2) identifying implementation strategy mechanisms focusing on health equity using mixed methods and oversampling populations that experience disparities. Participants (probands) in the active arms (health system \[Penn Medicine\]-mediated, Family Heart Foundation-mediated) will receive messaging that provides education about FH and provides instructions for participating in family cascade screening. A subset of probands will be invited to complete a qualitative interview about their experience receiving the implementation strategy. The research team will compare the active arms to Penn Medicine usual care for cascade screening to evaluate whether the active arms are more effective at promoting cascade screening than usual care.
Waitlist Available
Has No Placebo
University of Pennsylvania, Perelman School of Medicine
Have you considered Tricor clinical trials? We made a collection of clinical trials featuring Tricor, we think they might fit your search criteria.Go to Trials
Image of University of Maryland Amish Research Clinic in Lancaster, United States.

Direct Contact Genetic Screening for High Cholesterol

18+
All Sexes
Lancaster, PA
An important aspect of successful genomic medicine implementation is developing effective approaches for screening at-risk family members after probands are identified, also known as cascade screening. Most cascade screening studies conducted to date have been conducted outside the US, and very few studies have used a rigorous approach involving a comparator group or randomized controlled design. A major question in the field is how to most effectively implement cascade screening, given commonly cited communication barriers, while respecting privacy among probands and family members. This study will conduct a randomized controlled trial to assess direct contact of relatives by study team members vs indirect, or proband-initiated, contact. We will assess efficacy of the cascade screening intervention, patient-centered outcomes regarding mental, physical, and psychosocial outcomes in probands and family members, and implementation evaluation outcomes. Individuals who are known to carry the KCNQ1 Met224Thr or APOB Arg3527Gln variant will be eligible to participate. After providing consent and being deemed eligible, individuals will be randomized in a 1:1 manner into the direct or indirect contact of family members arm of the study. The randomization will be stratified by variant to ensure equal representation of each variant in the study arms. Individuals in the indirect arm will be instructed to contact their first-degree family members about the opportunity to be screened. They will be provided with a disease-specific pamphlet and a family letter explaining the cascade screening. In the direct arm, probands will be advised that the study staff will be contacting their family members. They will be instructed to also contact their family members prior to the study team contacting them. Approximately two weeks after this meeting with the proband, the study staff will mail letters to eligible first-degree family members of the probands. If we do not hear back from individual family members, we will follow-up with another letter, telephone call, or home visit. The information contained in the letters will be the same information for both the direct and indirect arms of the study. All interested family members will receive pre-test counseling and free, in-home, saliva-based genetic testing, and post-test counseling.
Recruiting
Has No Placebo
University of Maryland Amish Research Clinic
Have you considered Tricor clinical trials? We made a collection of clinical trials featuring Tricor, we think they might fit your search criteria.Go to Trials
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