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What is Dolobid
DiflunisalThe Generic name of this drug
Treatment SummaryDiflunisal is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation associated with arthritis. It works by blocking certain substances in the body that lead to inflammation. Diflunisal is prescribed to treat rheumatoid arthritis and osteoarthritis.
Diflunisalis the brand name
Dolobid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diflunisal
Diflunisal
1992
17
Approved as Treatment by the FDA
Diflunisal, also known as Diflunisal, is approved by the FDA for 4 uses which include Rheumatoid Arthritis and Pain .Rheumatoid Arthritis
Pain
Osteoarthritis
Mild pain
Effectiveness
How Dolobid Affects PatientsDiflunisal is a non-narcotic painkiller, anti-inflammatory, and fever reducer. It is not habit-forming and does not cause addiction. It is a slightly different form of salicylic acid, with two fluorine atoms replacing the 0-acetyl group on the carbon 4 position of aspirin. Diflunisal does not break down into salicylic acid in the body.
How Dolobid works in the bodyWe don't know exactly how diflunisal works, but it's thought to be related to its ability to reduce the amount of pain-causing and inflammation-causing molecules in the body. Diflunisal is a prostaglandin synthetase inhibitor, meaning it stops pain-causing and inflammation-causing molecules from forming. By decreasing the amount of these molecules, diflunisal helps reduce pain and inflammation.
When to interrupt dosage
The endorsed dosage of Dolobid is subject to the specified condition, such as Rheumatoid Arthritis, Mild pain and Pain. The measure of dosage wavers, in relation to the technique of delivery (e.g. Tablet - Oral or Oral) displayed in the table underneath.Condition
Dosage
Administration
Mild pain
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pain
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Rheumatoid Arthritis
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Osteoarthritis
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Dolobid.Common Dolobid Drug Interactions
Drug Name
Risk Level
Description
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Diflunisal.
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Diflunisal.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Diflunisal.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Diflunisal.
Mycophenolic acid
Major
The metabolism of Mycophenolic acid can be decreased when combined with Diflunisal.
Dolobid Toxicity & Overdose RiskThe toxic dose of diflunisal in rats, mice, and rabbits is 392mg/kg, 439mg/kg, and 603mg/kg, respectively. Overdosing on diflunisal can cause drowsiness, nausea, vomiting, diarrhea, rapid breathing, fast heartbeat, sweating, ringing in the ears, confusion, stupor, and coma. The smallest amount of diflunisal that has led to death is 15 grams. Taking diflunisal can increase the risk of serious heart problems such as heart attack and stroke in some patients. It can also cause ulcers
Dolobid Novel Uses: Which Conditions Have a Clinical Trial Featuring Dolobid?
75 active clinical trials are being carried out to explore the potential of Dolobid for alleviating Osteoarthritis (OA), Mild pain and Rheumatoid Arthritis.Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
59 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Pain
0 Actively Recruiting
Osteoarthritis
0 Actively Recruiting
Mild pain
0 Actively Recruiting
Dolobid Reviews: What are patients saying about Dolobid?
5Patient Review
4/21/2008 I've only been taking this for two weeks, but it has already alleviated the pain I experience in my lower back and hip area. As someone who works with their hands a lot, this has been huge. No side effects so far that I can tell, touch wood.
5Patient Review
8/9/2008 Out of all the NSAIDs I've tried, this one works best for me. It takes effect quickly, like aspirin, which is helpful when I need relief right away.
5Patient Review
3/27/2008 The Nabumetone 750 mg. bothered my stomach, so I was given this at 500 mg. and it helped tremendously!
5Patient Review
11/27/20075Patient Review
3/26/2009 As a nursing student, I found this medication to be very informative and helpful.
4.7Patient Review
5/28/2008 I stay away from NSAIDs because of FDA warnings.
4.3Patient Review
4/10/2014 Even when taken with food or milk, this medication was very harsh on my stomach. I didn't find it to be any more effective than over-the-counter ibuprofen.
4Patient Review
12/6/2015 Long-term or full seasonal use of Dolobid doesn't seem to result in any side effects, from what I can tell. Fioricet combined with Fexofenadine Hcl works well for migraines that are due to CBV during seasonal allergies--I've been using this method since 1995. When I visited the Philippines for a year and didn't have access to Fioricet, Diflunisal 500 mg worked well as a stopgap measure but it wasn't ideal.
4Patient Review
2/14/2011 This treatment helped with my swelling and bloating.
2.3Patient Review
3/2/2014 I find this medication helpful in terms of falling asleep; however, I often wake up during the night and have difficulty returning to sleep.
Patient Q&A Section about dolobid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is DOLOBID used for?
"Diflunisal is taken to help with mild to moderate pain that is caused by various conditions. Additionally, it can help reduce pain, swelling, and joint stiffness that is caused by arthritis. By reducing these symptoms, it becomes easier to do normal daily activities. This medication is classified as a nonsteroidal anti-inflammatory drug (NSAID)."
Answered by AI
Is DOLOBID same as ibuprofen?
"A study found that DOLOBID is just as effective as aspirin. The study was double-blind and lasted for 12 weeks, during which patients took different dosages of either DOLOBID or ibuprofen. The results showed that both drugs were effective and had a similar tolerability."
Answered by AI
Is DOLOBID discontinued?
"was a medication used to relieve pain and inflammation.
Dolobid was a medication used to relieve pain and inflammation, but it is no longer available in the U.S."
Answered by AI
Is DOLOBID a narcotic?
"DOLOBID is a non-steroidal drug that can be used to relieve pain, inflammation, and fever. It is a peripherally-acting non-narcotic analgesic drug."
Answered by AI