Metolazone

Hypertensive disease, Swollen feet or ankles, Chronic Kidney Disease (CKD) + 3 more
Treatment
2 FDA approvals
20 Active Studies for Metolazone

What is Metolazone

MetolazoneThe Generic name of this drug
Treatment SummaryMetolazone is a long-acting diuretic used to treat chronic renal failure. It helps reduce blood pressure and causes the body to lose potassium. It belongs to a class of drugs called quinazoline-sulfonamides, which are similar to thiazide diuretics.
Metolazoneis the brand name
image of different drug pills on a surface
Metolazone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Metolazone
Metolazone
1973
81

Approved as Treatment by the FDA

Metolazone, also known as Metolazone, is approved by the FDA for 2 uses which include Hypertensive disease and Hypertensive disease .
Hypertensive disease
Used in combination with Hydrochlorothiazide / Losartan to help manage High Blood Pressure (Hypertension)
Hypertensive disease
Helps manage moderate Hypertension

Effectiveness

How Metolazone Affects PatientsMetolazone is a diuretic, which helps the body get rid of excess fluid. It works in a similar way to thiazide diuretics. Studies have shown that metolazone increases the amount of phosphate, magnesium, and sodium that is excreted from the body in people with poor kidney function. It has also been shown to work on animals in laboratory studies.
How Metolazone works in the bodyMetolazone affects how the kidney reabsorbs electrolytes, specifically sodium and chloride. It prevents the absorption of these electrolytes, which causes increased excretion of them in urine. This also increases the amount of potassium that is excreted in urine. Metolazone does not affect carbonic anhydrase. The exact way that metolazone helps lower blood pressure is not known, but it is thought to be related to its effects on electrolyte excretion.

When to interrupt dosage

The measure of Metolazone is contingent upon the diagnosed affliction, including Mild Hypertension, Hypertensive disease and Hypertensive disease. The dosage amount is contingent upon the methodology of delivery featured in the table beneath.
Condition
Dosage
Administration
Hypertensive disease
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Tablet - Oral, Tablet, Oral
Swollen feet or ankles
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Tablet - Oral, Tablet, Oral
Chronic Kidney Disease (CKD)
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Tablet - Oral, Tablet, Oral
Hypertension
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Tablet - Oral, Tablet, Oral
Hypertensive disease
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Tablet - Oral, Tablet, Oral
Congestive Heart Failure
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Tablet - Oral, Tablet, Oral

Warnings

Metolazone has three contraindications, and it should be avoided for the conditions listed in the table below.Metolazone Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic Encephalopathy
Do Not Combine
Coma
Do Not Combine
There are 20 known major drug interactions with Metolazone.
Common Metolazone Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Metolazone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Metolazone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Metolazone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Metolazone is combined with Hexamethonium.
Lithium carbonate
Major
Metolazone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Metolazone Toxicity & Overdose RiskOverdosing on this drug can cause difficulty breathing, dizziness, feeling faint upon standing, drowsiness, stomach and intestinal irritation, and extreme fatigue which can lead to a coma.
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Metolazone Novel Uses: Which Conditions Have a Clinical Trial Featuring Metolazone?

Presently, 314 active studies are being conducted to examine the potential of Metolazone in treating Congestive Heart Failure, Hypertension and Swelling.
Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
28 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4
Swollen feet or ankles
5 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypertension
0 Actively Recruiting
Congestive Heart Failure
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
0 Actively Recruiting

Metolazone Reviews: What are patients saying about Metolazone?

5Patient Review
9/11/2012
Metolazone for Accumulation of Fluid Resulting from Chronic Heart Failure
This pill is very effective at removing fluid. I take it once a week as instructed, and I can really see (and feel) the difference.
5Patient Review
1/17/2018
Metolazone for Accumulation of Fluid Resulting from Chronic Heart Failure
This diuretic has worked very well for me. I started seeing results within a few days, and my potassium levels dropped after about a week.
5Patient Review
5/11/2012
Metolazone for High Blood Pressure
I am so thankful that this medication exists! Not only did it lower my blood pressure, but the edema in my ankles and feet completely disappeared.
5Patient Review
7/11/2010
Metolazone for Accumulation of Fluid Resulting from Chronic Heart Failure
This drug was added to my regimen when I needed additional help.
5Patient Review
12/8/2009
Metolazone for High Blood Pressure
This pill is for depression and it has a letter 'M' and the #645 on one side of the pill. The other side is blank. I'm not sure if this is the right pill for my daughter.
4.7Patient Review
12/18/2009
Metolazone for Accumulation of Fluid Resulting from Chronic Heart Failure
This drug, in combination with lasix, has been working great for me. I have stage 4 kidney failure as well as COPD and congestive heart failure, so this two-drug combo is essential for keeping my lungs and heart functioning properly. When my blood work starts to show that my kidneys are failing, I take a break from the duo for a couple weeks.
4.3Patient Review
1/9/2010
Metolazone for Accumulation of Fluid Resulting from Chronic Heart Failure
This treatment appears to be effective.
3.7Patient Review
4/6/2013
Metolazone for Fluid in the Lungs due to Chronic Heart Failure
I've only been on a small dose of this medication, but it has already helped me. However, my heart rate is now irregular. I'm wondering if this is something I will get used to after awhile?
3.7Patient Review
12/29/2009
Metolazone for Accumulation of Fluid Resulting from Chronic Heart Failure
I take this for congestive heart failure alongside lasix and aldactone. It's helped a little bit, but I'm on such a low dose (2.5mg) that it might just need to be increased. Within two days, it noticeably reduces bloating.
1.7Patient Review
11/27/2020
Metolazone for Accumulation of Fluid Resulting from Chronic Heart Failure
Metolazone is really not a good choice, especially if you're looking at long-term use. I have to take it for fluid buildup and every time my potassium levels drop critically low, which has led to acute kidney failure in the past. However, I don't have any other choice because the Torsemide that I take daily has all but stopped working. If you can avoid this drug, it would be best for you.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about metolazone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects for metolazone?

"The following are symptoms of dehydration: dizziness, weakness, restlessness, headache, muscle cramps, joint pain or swelling, constipation, diarrhea."

Answered by AI

Is metolazone a potassium sparing diuretic?

"Metolazone prevents the reabsorption of sodium, potassium, and water in the tubules, causing an increase in their excretion."

Answered by AI

Is metolazone the same as Lasix?

"Lasix (furosemide) and Zaroxolyn (metolazone) are diuretics that are used to treat excess accumulation of fluid or swelling of the body (edema). They are also used to treat high blood pressure (hypertension)."

Answered by AI

Is metolazone a strong diuretic?

"Even at low doses, metolazone significantly increases the diuretic effects of furosemide, making it simpler to treat fluid retention. In many cases, high doses of furosemide can be avoided, which is an advantage for patients who need long-term treatment and have decreased kidney function."

Answered by AI

Clinical Trials for Metolazone

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Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Metolazone clinical trials? We made a collection of clinical trials featuring Metolazone, we think they might fit your search criteria.Go to Trials
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Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Have you considered Metolazone clinical trials? We made a collection of clinical trials featuring Metolazone, we think they might fit your search criteria.Go to Trials
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Endovascular Treatment for Stroke

18+
All Sexes
Richmond, VA
Endovascular therapy (EVT) has proven to be more beneficial for patients with AIS caused by large vessel occlusions (LVO) than medical management alone. A recent meta-analysis of 5 RCTs showed that EVT significantly reduced disability at 90 days compared to medical management \[1\]. Despite its obvious benefits, patients may have neurological deterioration despite successful thrombectomy due to ischemia progression, intracranial hemorrhage, re-occlusion, or vasogenic edema. The incidence of early neurological deterioration (END) following EVT for acute stroke has been reported to be ranging from 14.1-35.2% with some studies defining END up to 7 days and some restricting the definition between 6-72 hours post thrombectomy. A small proportion of these patients, approximately 5.9-10.5%, experienced sICH following EVT. Whether END occurs due to ischemic or hemorrhagic it leads to worse outcomes.
Waitlist Available
Has No Placebo
Virginia Commonwealth UniversityAarti Sarwal
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Extended vs Immediate Release Torsemide for Heart Failure

18+
All Sexes
Miami, FL
The primary objective of this study is to learn whether a morning dose of extended-release torsemide enhances renal sodium excretion after lunch (4-8 hours after dosing) compared to immediate-release torsemide. This is a randomized, double-blind, crossover study in patients with heart failure who are on a stable dose of a loop diuretic. During the study period, participants' current loop diuretics will be replaced with an equivalent dose of either immediate-release or extended-release torsemide. Following a one-week stabilization period on the assigned torsemide formulation, patients will report to the clinical site for an assessment visit. On the study day, patients will take a single dose of the same torsemide formulation they have been on for the past week, administered after breakfast. Urine samples be collected are: * 0-4 hours post-dosing (pre-lunch period) * 4-8 hours post-dosing (post-lunch period) * 8-24 hours post-dosing (24 hours period) The primary endpoint will be urinary sodium excretion (4-8 hours after dosing). This will be compared between the extended-release arm and the immediate-release arm to assess the efficacy of prolonged diuretic action. In addition, urinary potassium and creatinine excretion and creatinine clearance will be measured in all urine samples as the safety endpoints.
Phase 4
Recruiting
Future Life Clinical TrialsSalim Shah, PhD, JDSarfez Pharmaceuticals, Inc.
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Inspire HER for Cardiovascular Disease

30 - 79
Female
Birmingham, AL
Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group. We will refine and conduct a randomized, wait-list controlled trial of Inspire HER (a heart health lifestyle intervention for Black women that provides health education, physical activity, and social resources). We will also compare Inspire HER and Black Impact (a heart health intervention for Black men) data to study how women and men respond differently to stress. This trial aligns with American Heart Association's pledge to address heart health equity through new interventions that consider the person and the circumstances with which they live.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamTimiya S Nolan, PhD
Have you considered Metolazone clinical trials? We made a collection of clinical trials featuring Metolazone, we think they might fit your search criteria.Go to Trials
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