Your session is about to expire
What is Zyprexa Zydis
OlanzapineThe Generic name of this drug
Treatment SummaryOlanzapine is an atypical antipsychotic medication used to treat mental health conditions. It was introduced in the 1990s and is known for its effectiveness, reduced risk of side effects and low chance of drug-drug interactions. Olanzapine is similar to clozapine but has two additional methyl groups and no chloride moiety. It was approved by the FDA and released in the US in 1996.
Zyprexais the brand name
Zyprexa Zydis Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyprexa
Olanzapine
1996
546
Approved as Treatment by the FDA
Olanzapine, otherwise known as Zyprexa, is approved by the FDA for 8 uses which include Mental Depression and Bipolar Disorder .Mental Depression
Used to treat Acute Depressive Episode in combination with Fluoxetine
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Fluoxetine
Bipolar Disorder With Manic or Mixed Episodes
Used to treat Bipolar Disorder With Manic or Mixed Episodes in combination with Lithium cation
Bipolar 1 Disorder
Used to treat Bipolar 1 Disorder in combination with Fluoxetine
Acute Depressive Episode
Used to treat Acute Depressive Episode in combination with Fluoxetine
Major depressive disorder, recurrent episode
Used to treat Major depressive disorder, recurrent episode in combination with Fluoxetine
Bipolar Disorder
Used to treat Bipolar Disorder With Manic or Mixed Episodes in combination with Lithium cation
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Fluoxetine
Effectiveness
How Zyprexa Zydis Affects PatientsOlanzapine works by targeting the dopamine D2 receptor and the serotonin 5HT2A receptor in the body. This helps to decrease hallucinations, delusions, disorganized speech, disorganized thought, and disorganized behavior, as well as improve feelings of sadness, lack of energy, lack of interest in activities, difficulty making decisions, and poor attention. Olanzapine has been shown to be effective in treating schizophrenia and bipolar disorder in adults and reducing manic or mixed episodes in adolescents. It has also been studied for its ability to reduce nausea and vomiting caused by chemotherapy, with studies showing that it can help control these symptoms in over 80
How Zyprexa Zydis works in the bodyOlanzapine works by blocking receptors in the brain, including receptors for dopamine and serotonin. This blocking prevents dopamine from having an effect on the post-synaptic receptor. Olanzapine also blocks serotonin receptors in the frontal cortex, which helps reduce side effects.
When to interrupt dosage
The advised dosage of Zyprexa Zydis is contingent upon the recognized condition, such as Schizophrenia, Bipolar Disorder and Delirium. The measure of dosage fluctuates as per the method of administration (e.g. Kit - Intramuscular or Tablet, film coated - Oral) detailed in the table beneath.Condition
Dosage
Administration
Delirium
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Schizophrenia
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Schizophrenia
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Post Traumatic Stress Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Tourette Syndrome
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Mental Depression
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Acute Agitation
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Unipolar Depression
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Acute Coryza
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Delusional Parasitosis
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Alzheimer's Disease
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Warnings
There are 20 known major drug interactions with Zyprexa Zydis.Common Zyprexa Zydis Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Olanzapine.
Acepromazine
Major
Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Olanzapine is combined with Aclidinium.
Alfuzosin
Major
Olanzapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Olanzapine may increase the antipsychotic activities of Amisulpride.
Zyprexa Zydis Toxicity & Overdose RiskTaking too much olanzapine can cause drowsiness, enlarged pupils, slow or shallow breathing, low blood pressure, muscle stiffness, dry mouth, and confusion. In more severe cases, people may experience agitation, slurred speech, fast heartbeat, and reduced consciousness. In rare cases, taking too much olanzapine can even lead to death. If someone has overdosed on olanzapine, it is important to ensure they are getting enough oxygen and to give them activated charcoal with a laxative. Animal studies have linked olanzapine to an increased risk of liver tumors, mammary gland tumors
Zyprexa Zydis Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyprexa Zydis?
At present, 578 active clinical trials are evaluating the potential of Zyprexa Zydis to alleviate Schizophrenia, Post Traumatic Stress Disorder and Delusional Parasitosis.Condition
Clinical Trials
Trial Phases
Schizophrenia
112 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4, Phase 3, Phase 2, Phase 1
Bipolar Disorder
0 Actively Recruiting
Post Traumatic Stress Disorder
221 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Schizophrenia
36 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Mental Depression
2 Actively Recruiting
Not Applicable
Delirium
26 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1
Unipolar Depression
49 Actively Recruiting
Not Applicable, Early Phase 1, Phase 3, Phase 4, Phase 2, Phase 1
Bipolar Disorder
0 Actively Recruiting
Bipolar Disorder
0 Actively Recruiting
Delusional Parasitosis
0 Actively Recruiting
Alzheimer's Disease
36 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1
Acute Coryza
1 Actively Recruiting
Not Applicable
Acute Agitation
0 Actively Recruiting
Tourette Syndrome
0 Actively Recruiting
Zyprexa Zydis Reviews: What are patients saying about Zyprexa Zydis?
5Patient Review
2/18/2012 Zydis has really helped me. I've experienced an increase in appetite and weight gain, but it's worth it for the relief it provides.
5Patient Review
7/19/2009 I found this medication to be really great. I had no issues with weight gain, depression, anxiety, or concentration at a dose of 10 mg at night.
5Patient Review
1/10/2009 I am so pleased with this medication. I only wish I had started taking it sooner.
5Patient Review
12/2/2008 If you've gained weight, get active and go to the gym or something! Zyprexa has always worked for me and I haven't had any issues for years now.
3.7Patient Review
10/2/2009 I am a 240 pound, 5'5" male with high cholesterol and triglycerides.
3.3Patient Review
4/13/2009 Worked great at first, but then the effects petered out after a few months. I still experienced some side effects even after it stopped being effective which were mostly increased appetite and fatigue. Your experience may be different, but mine was not good.
3Patient Review
11/6/2007 I find that if I don't take this medication, I feel more anxious; however, it doesn't seem to do much else. The downside is that I've experienced severe weight gain as a result of taking it.
3Patient Review
4/23/2012 This medication was successful in curbing her manic episodes of anxiety and anger. However, once it hit her system she became incredibly depressed and would cry for hours on end. We haven't decided if we will continue using it yet.
3Patient Review
8/25/2011 My weight has been more unstable since I began taking this medication.
2.7Patient Review
12/28/2007 I've found that my symptoms have actually gotten worse since starting this medication, and I've also gained weight.
1Patient Review
11/10/2009 I haven't tried it yet.
1Patient Review
5/25/2014 I gained a ton of weight in just three weeks from using this. Please, look for something else!
Patient Q&A Section about zyprexa zydis
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Zyprexa and Zyprexa Zydis the same thing?
"Zyprexa Zydis wafers are just as effective as Zyprexa coated tablets, with a similar rate and extent of absorption. Zyprexa Zydis wafers have the same dosage and frequency of administration as Zyprexa coated tablets. Zyprexa Zydis wafers may be used as an alternative to Zyprexa coated tablets."
Answered by AI
How long does it take for Zyprexa Zydis to dissolve?
"For treating bipolar disorder on a long-term basis, the recommended dose of olanzapine is 5-20 mg per day. The orally disintegrating tablet form of olanzapine is placed in your mouth, where it will dissolve within a few seconds."
Answered by AI
How do you administer Zyprexa Zydis?
"To take ZYPREXA ZYDIS (olanzapine orally disintegrating tablets), open the sachet and peel back the foil on the blister. Do not push the tablet through the foil. Using dry hands, remove the tablet from the blister and place the entire tablet in your mouth."
Answered by AI
What is Zyprexa Zydis used for?
"Olanzapine belongs to a class of drugs called atypical antipsychotics.
Olanzapine is a drug used to treat mental and mood conditions such as schizophrenia and bipolar disorder. It may also be used to treat depression in combination with other medications. Olanzapine belongs to a class of drugs called atypical antipsychotics."
Answered by AI