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What is Picato
Ingenol mebutateThe Generic name of this drug
Treatment SummaryIngenol mebutate, sold under the brand name Picato®, is a topical gel used to treat actinic keratosis. It is derived from a plant called Euphorbia peplus, whose sap has been used for centuries to treat skin conditions such as warts and cancer. In addition, it has been found to have powerful anti-leukemia effects, capable of killing myeloid leukemia cells and primary AML cells at very low concentrations. Ingenol mebutate was approved by the FDA in 2012.
Picatois the brand name
Picato Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Picato
Ingenol mebutate
2012
2
Effectiveness
How Picato Affects PatientsIt is not known how ingenol mebutate works to cause cell death in actinic keratosis.
How Picato works in the bodyThe way ingenol mebutate works against actinic keratosis is not entirely clear. It likely involves killing the cells first, then triggering an immune response to finish off any remaining cells. Studies have also shown that ingenol mebutate activates and moves certain proteins into the nucleus and membranes of cells, and decreases the activity of some other proteins. This leads to the activation of certain pathways in the cell, which helps stop the disease from progressing.
When to interrupt dosage
The amount of Picato is contingent upon the diagnosed affliction. The degree of dosage fluctuates as per the technique of delivery (e.g. Topical or Gel) featured in the table below.Condition
Dosage
Administration
Actinic Keratosis
0.015 %, , 0.05 %, 0.0005 mg/mg, 0.00015 mg/mg
, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous
Warnings
Common Picato Drug Interactions
Drug Name
Risk Level
Description
Picato Toxicity & Overdose RiskCommon side effects of using this drug include skin irritation or redness at the application site, headaches, puffiness or swelling around the eyes, and inflammation of the nose and throat.
Picato Novel Uses: Which Conditions Have a Clinical Trial Featuring Picato?
An ongoing examination is assessing the potential of Picato to address Actinic Keratosis.Condition
Clinical Trials
Trial Phases
Actinic Keratosis
12 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4
Picato Reviews: What are patients saying about Picato?
5Patient Review
11/26/2019 Picato was great for me, no pain at all. Only thing was that my skin felt a little tight after using it, but the crusty bits fell off soon enough. I'm just curious if anyone knows if you can put makeup or face powder on new pink skin?
4.7Patient Review
4/20/2017 I used this three times and my pre-cancer lower lip has improved. The side effects were minor compared to another medication
4.3Patient Review
10/5/2017 This medication is effective, though results may vary from person to person. I've used it three times with different responses each time. This last round of treatment has been the most successful in terms of reducing redness and swelling.
4.3Patient Review
5/14/2019 I only had to use this gel three times over the course of three days, which was awesome. The tradeoff was that it caused a little redness and irritation, but it did get rid of the scaly patches, so I'm happy.
2.3Patient Review
3/22/2017 If you have sensitive skin, I would recommend avoiding this treatment. My face became incredibly swollen and painful after just a small amount was applied. It's very expensive too, so it wasn't worth it for me.
2.3Patient Review
10/19/2017 I used this on an AK above my lip. I tried not to let it touch my lips, as the directions said not to use it on them. I used it at bedtime, which you are not supposed to do, I learned later. During the night, it was stinging a lot, and I rinsed it off after six hours. By morning, my lip looked swollen and red. After reading other reviews, I discontinued use rather than risk worsening effects.
1.7Patient Review
3/31/2020 Efudex is much more effective than this treatment. Save your time and money.
1Patient Review
3/8/2019 I'm not going to use this gel based on the reviews I've read. It seems like a really painful procedure with no guarantee of success, and I don't understand why a doctor would recommend it over other options.
Patient Q&A Section about picato
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Picato cream used for?
"Picato is a medication that comes in the form of a gel. It is applied to areas of the skin affected by actinic keratosis, which is a condition caused by too much exposure to sunlight. If left untreated, actinic keratosis can turn into skin cancer."
Answered by AI
Is Picato better than efudex?
"Picato, a cream developed in Australia, is used in a similar way to efudix, but the treatment times are shorter (once a day for either 2 or 3 days, depending on where it is used). The reactions to it tend to be more severe than to efudix, including blistering."
Answered by AI
Why was Picato discontinued?
"- LEO Pharma announces the discontinuation of Picato gel due to business reasons. This decision is not based on any safety, efficacy or quality concerns. The phase-out process is expected to be completed by the end of 2020."
Answered by AI
What does Picato do to the skin?
"Picato gel is a topical medication prescribed to treat a condition called actinic keratosis. The active ingredient in Picato gel is derived from a plant, and it works by killing the cells that comprise the scaly skin patch."
Answered by AI