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[F-18]MeFAMP PET for Brain Tumors
Phase < 1
Waitlist Available
Led By Jonathan McConathy, MD, PhD
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
18 years of age or older at the time of enrollment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from injection to 45 minutes, 2 hours, and 4 hours after pet agent administration.
Awards & highlights
No Placebo-Only Group
Summary
This trial will test if a new imaging tech is safe and effective for imaging brain tumors. It will also explore if it can accurately distinguish tumors from radiation effects.
Who is the study for?
This trial is for adults over 18 with a life expectancy of more than 12 weeks. It includes healthy volunteers, those with high-grade glioma after radiation, and patients with brain metastases from other tumors. Women able to have children must test negative for pregnancy.
What is being tested?
[F-18]MeFAMP PET imaging is being tested to see if it's safe and how well it can show primary and metastatic brain tumors. The study has three parts: one for healthy people, one for glioma patients, and another for those with brain metastases.
What are the potential side effects?
Since this is the first time [F-18]MeFAMP PET is used in humans, part of the study aims to establish its safety profile. Potential side effects are not detailed but will be monitored throughout the trial.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ from injection to 45 minutes, 2 hours, and 4 hours after pet agent administration.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from injection to 45 minutes, 2 hours, and 4 hours after pet agent administration.
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Human dosimetry for [F-18]MeFAMP.
Safety of [F-18]MeFAMP
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
3Treatment groups
Experimental Treatment
Group I: High Grade Glioma (cohort 2)Experimental Treatment1 Intervention
Recurrent high grade glioma after radiation therapy
Group II: Healthy Volunteers (cohort 1)Experimental Treatment1 Intervention
Whole Body Dosimetry for healthy volunteers
Group III: Brain Metastasis (cohort 3)Experimental Treatment1 Intervention
Brain metastases from extra-cranial solid tumors before and after radiation therapy
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Who is running the clinical trial?
University of Alabama at BirminghamLead Sponsor
1,646 Previous Clinical Trials
2,342,745 Total Patients Enrolled
Jonathan McConathy, MD, PhDPrincipal InvestigatorUniversity of Alabama at Birmingham
5 Previous Clinical Trials
146 Total Patients Enrolled
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