Combination Cream for Squamous Cell Carcinoma

Phase < 1

Recruiting

Led By Mariana Phillips, MD

Research Sponsored by Carilion Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6-8 wks

Awards & highlights

All Individual Drugs Already Approved

Approved for 5 Other Conditions

Summary

This trial tests if combining two creams can effectively treat certain skin cancers with minimal scarring and fewer side effects. It targets patients with specific types of squamous cell carcinoma on the trunk and upper extremities. The treatment works by boosting the immune system and directly killing cancer cells.

Eligible Conditions

Squamous Cell Carcinoma

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6-8 wks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6-8 wks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6-8 wks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Cancer resolution on histopathology

Secondary study objectives

Cosmetic appearance

Final scar length

Awards & Highlights

All Individual Drugs Already Approved

Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Approved for 5 Other Conditions

This treatment demonstrated efficacy for 5 other conditions.

Trial Design

3Treatment groups

Experimental Treatment

Placebo Group

Group I: 7 day medication groupExperimental Treatment1 Intervention

The 7 day medication group will apply combination topical 5-fluorouracil 5% / calcipotriene 0.005% cream twice per day for 7 days.

Group II: 14 day medication groupExperimental Treatment1 Intervention

The 14 day medication group will apply combination topical 5-fluorouracil 5% / calcipotriene 0.005% cream twice per day for 14 days.

Group III: Placebo groupPlacebo Group1 Intervention

10 patients will be divided into 7 and 14 day treatment groups with 5 patients each. They will apply Nourivan base cream from Pure Science Rx, twice per day for their designated time.

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