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Ketamine for Electroconvulsive Therapy

Phase < 1
Waitlist Available
Research Sponsored by University of New Mexico
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up this will be assessed throughout the year.
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a treatment for depression using electric shocks to the brain while patients are asleep with either ketamine or methohexital. The goal is to see how slow brain waves change during the treatment and if these changes can show how well the treatment is working. Ketamine has long been used as an alternative anesthetic for ECT and appears to initially enhance the benefits of ECT.

Eligible Conditions
  • Migraine Aura
  • Electroconvulsive Therapy
  • Electroencephalogram
  • Ketamine

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of Participants Assessed for Clinical Efficacy of ECT
Secondary study objectives
Cognitive performance
Direct current electroencephalogram slow wave phenomenon (exploratory outcome)
ECT parameters and their correlation to production of slow-wave phenomenon

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: KetamineExperimental Treatment1 Intervention
Standard of care anesthesia that suppresses slow wave characteristics
Group II: MethohexitalActive Control1 Intervention
Standard of care anesthesia that does not affect slow wave characteristics
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine
2011
Completed Phase 4
~1120

Find a Location

Who is running the clinical trial?

University of New MexicoLead Sponsor
384 Previous Clinical Trials
3,525,943 Total Patients Enrolled
~2 spots leftby Nov 2025
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