Pioglitazone for Gastroparesis

(PIOGAS Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Glenn J Treisman, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Waitlist Available

Sponsor: Johns Hopkins University

No Placebo Group

Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?

This trial is testing whether pioglitazone, a diabetes medication, can help adults with chronic nausea and vomiting due to gastroparesis. The medication works by reducing inflammation and improving insulin response, which might improve stomach function.

Eligibility Criteria

Adults with Idiopathic Gastroparesis, confirmed by gastric emptying tests, can join this trial. They must have ongoing symptoms like nausea and vomiting. Pregnant or nursing individuals, those under 18, with a history of bladder cancer or significant liver disease, recent severe heart issues, uncontrolled other diseases that could explain symptoms, previous upper GI tract surgery or diabetes are excluded.

Inclusion Criteria

Females will be required to use adequate contraceptive methods during study participation as determined by the Principal Investigator and the study team members

I am 18 years old or older.

I experience ongoing symptoms like nausea, vomiting, bloating, and abdominal pain due to gastroparesis.

Exclusion Criteria

You have high blood sugar, as indicated by a test called HbA1c or fasting blood sugar.

I or someone in my family has had bladder cancer.

I have had surgery on my upper stomach area.

Participant Groups

The study is testing if Pioglitazone (30 mg) taken for 8 weeks improves gastroparesis symptoms based on the Gastrointestinal Symptom Index scores. It's designed to see if this treatment helps reduce problems like nausea and abdominal pain in patients without clear causes for their condition.

Group I: Pioglitazone Experimental Treatment 1 Intervention

Candidates who after the screening period are eligible to receive Pioglitazone

Pioglitazone is already approved in United States for the following indications:

🇺🇸 Approved in United States as Actos for:

• Type 2 diabetes mellitus

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Johns Hopkins Bayview Medical Center Baltimore, MD

Who Is Running the Clinical Trial?

Johns Hopkins University Lead Sponsor

References