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Alkalinizing Agent

Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD

Aurora, CO
Phase < 1
Waitlist Available
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 12 months

Summary

This trial is testing whether sodium bicarbonate can improve cognitive and cerebrovascular function in patients with CKD stage 3b-4 who have metabolic acidosis.

See full description
Eligible Conditions
  • Acidosis
  • Chronic Kidney Disease
  • Cognitive Impairment
  • Mild Cognitive Impairment

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Cognitive Function Composite Score at 12 Months
Change in Crystallized Cognition Composite Score at 12 Months
Change in Fluid Cognition Composite Score at 12 Months
Secondary study objectives
Change in Cerebrovascular Reactivity at 12 Months
Percent Change in Mean Blood Flow Velocity of the Middle Cerebral Artery at 12 Months

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Sodium bicarbonateExperimental Treatment1 Intervention
Sodium bicarbonate will be used at a dose of 0.5 mEq/kg-lean body weight/day.
Group II: PlaceboPlacebo Group1 Intervention
Placebo medication will be used at a dose of 0.5 mEq/kg-lean body weight/day
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sodium Bicarbonate Tablets
2021
Completed Early Phase 1
~40

Find a Location

Closest Location:University of Colorado Anschutz Medical Campus· Aurora, CO

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor
1,830 Previous Clinical Trials
3,025,646 Total Patients Enrolled
~7 spots leftby Feb 2026