← Back to Search

lapatinib + radiation therapy for Carcinoma

Phase < 1
Waitlist Available
Led By Andrew S. Poklepovic, MD
Research Sponsored by Virginia Commonwealth University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 years
Awards & highlights
No Placebo-Only Group
All Individual Drugs Already Approved
Approved for 5 Other Conditions

Summary

Lapatinib will prevent radiation-induced increase in Transforming Growth Factor alpha (TGFα), an important growth factor in cancer cell recovery after ionizing irradiation.

Eligible Conditions
  • Carcinoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
TGFalpha

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: lapatinib + radiation therapyExperimental Treatment2 Interventions
lapatinib given orally 2-4 hours prior to first fraction of radiation
Group II: No therapy prior to radiationActive Control1 Intervention
Radiation therapy alone
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Radiation therapy
2013
Completed Phase 3
~2850
Lapatinib
FDA approved

Find a Location

Who is running the clinical trial?

Virginia Commonwealth UniversityLead Sponsor
713 Previous Clinical Trials
22,888,475 Total Patients Enrolled
7 Trials studying Carcinoma
269 Patients Enrolled for Carcinoma
Andrew S. Poklepovic, MDPrincipal InvestigatorMassey Cancer Center
3 Previous Clinical Trials
74 Total Patients Enrolled
~0 spots leftby Oct 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top