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Virus Therapy

PSMA-Targeted Trillium Compounds + PTI-122 for Prostate Cancer

Phase < 1
Waitlist Available
Research Sponsored by Ratio Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up over 168 hours post-injection
Awards & highlights
No Placebo-Only Group

Summary

This trial tests special compounds that target prostate cancer cells in men with advanced disease. These compounds are labeled with a radioactive substance to track them in the body and are tested with and without a protective agent to see if it reduces side effects.

Eligible Conditions
  • Prostate Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~over 168 hours post-injection
This trial's timeline: 3 weeks for screening, Varies for treatment, and over 168 hours post-injection for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Amount of radioactivity in blood
Amount of radiotracer absorbed by organs
Amount of radiotracer absorbed by tumor
Secondary study objectives
Amount of PTI-122 in blood
Incidence of adverse events

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: Trillium Compound AloneExperimental Treatment1 Intervention
Single dose of PSMA-Targeted \[In-111\]-Labeled Trillium Compound
Group II: Trillium Compound + Single Dose PTI-122Experimental Treatment2 Interventions
Single dose of PSMA-Targeted \[In-111\]-Labeled Trillium Compound plus single dose of PTI-122 at 5, 10 or 15 mg
Group III: Trillium Compound + Multiple Dose PTI-122Experimental Treatment2 Interventions
Single dose of PSMA-Targeted \[In-111\]-Labeled Trillium Compound plus two doses of PTI-122 at the preferred dose level
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PSMA-Targeted [In-111]-Labeled Trillium Compound
2022
Completed Early Phase 1
~30
PTI-122
2022
Completed Early Phase 1
~30

Find a Location

Who is running the clinical trial?

Ratio Therapeutics, Inc.Lead Sponsor
John Babich, PhDStudy DirectorRatio Therapeutics, Inc.

Media Library

PSMA-Targeted [In-111]-Labeled Trillium Compound (Virus Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05773703 — Phase < 1
Prostate Cancer Research Study Groups: Trillium Compound Alone, Trillium Compound + Single Dose PTI-122, Trillium Compound + Multiple Dose PTI-122
Prostate Cancer Clinical Trial 2023: PSMA-Targeted [In-111]-Labeled Trillium Compound Highlights & Side Effects. Trial Name: NCT05773703 — Phase < 1
PSMA-Targeted [In-111]-Labeled Trillium Compound (Virus Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05773703 — Phase < 1
~8 spots leftby Dec 2025
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