Nitrate Supplementation for Metabolic Syndrome

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Waitlist Available

Sponsor: Penn State University

No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to determine if beetroot juice consumption can improve cognitive performance and brain vascular function in individuals with metabolic syndrome

Eligibility Criteria

This trial is for adults aged 55-75 with metabolic syndrome, defined by having at least three of these: high triglycerides, low HDL cholesterol, large waist circumference, high blood pressure, or elevated fasting blood glucose. It's open to all genders and ethnicities but excludes smokers, those on nitrates or certain other medications like Viagra or anti-inflammatories, premenopausal women, individuals with active cancer or severe diseases.

Inclusion Criteria

I am between 55 and 75 years old.

Your "good" cholesterol (HDL) levels are too low.

This criterion does not exclude anyone based on their race or ethnicity.

Exclusion Criteria

I have difficulty seeing.

My cancer is currently active.

My depression score indicates moderate to severe depression.

Participant Groups

The study tests if drinking beetroot juice can boost brain function and cognition in people with metabolic syndrome. Participants will be randomly given either real beetroot juice (active) or a placebo version without its active ingredients to compare effects.

Group I: Metabolic Syndrome Older Adult - Placebo juice condition Experimental Treatment 1 Intervention

Participants with metabolic syndrome will be drinking nitrate rich beetroot juice from the James White Beet It company. Participants will drink one dose of 140mL beetroot juice for two visits of either a nitrate rich juice or a nitrate depleted placebo drink. Both drinks taste and smell the same, just with the active component removed. Following these visits, participants will drink 70ml of nitrate rich beetroot juice daily for 4 weeks to investigate long term effects of the juice on study outcomes.

Group II: Metabolic Syndrome Older Adult Experimental Treatment 1 Intervention

Participants with metabolic syndrome will be drinking nitrate rich beetroot juice from the James White Beet It company. Participants will drink one dose of 140mL beetroot juice for two visits of either a nitrate rich juice or a nitrate depleted placebo drink. Both drinks taste and smell the same, just with the active component removed. Following these visits, participants will drink 70ml of nitrate rich beetroot juice daily for 4 weeks to investigate long term effects of the juice on study outcomes.

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Penn State University, Noll Lab University Park, PA

Who Is Running the Clinical Trial?

Penn State University Lead Sponsor

References