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Topical Steroid

Topical Medications for Healthy Subjects

Phase 1
Recruiting
Led By Emanual Maverakis, MD
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Individuals with known chronically active skin diseases, including atopic dermatitis, psoriasis, seborrheic dermatitis, other autoimmune and inflammatory skin conditions
Individuals younger than 18 years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks after initial dispensing
Awards & highlights
No Placebo-Only Group

Summary

This trial will help researchers understand how commonly used topical medications affect the human microbiome.

Who is the study for?
This trial is for adults over 18 who speak English and haven't used antibiotics in the last 6 months. It's not for those with chronic skin diseases, allergies to study medications, inability to consent, prisoners, or a history of skin cancer.
What is being tested?
The study tests how two topical treatments—Ketoconazole (an antifungal cream) and Desonide (a low potency steroid ointment)—affect the human skin microbiome after short-term use.
What are the potential side effects?
Potential side effects may include local irritation, redness, itching at the application site from Ketoconazole or Desonide. Long-term use can lead to more serious side effects but this study focuses on short-term usage.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a long-term skin condition like eczema, psoriasis, or similar.
Select...
I am under 18 years old.
Select...
I am unable to give consent for medical procedures.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks after initial dispensing
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks after initial dispensing for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of bacteria per each species
Secondary study objectives
Number of species at test sites

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Ketoconazole 2%Experimental Treatment1 Intervention
Antifungal topical medication applied to specific locations on the face and extremities, twice daily for two weeks
Group II: Desonide 0.05%Experimental Treatment1 Intervention
Low potency steroid topical medication applied to specific locations on the face and extremities, twice daily for two weeks

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of California, DavisLead Sponsor
943 Previous Clinical Trials
4,755,664 Total Patients Enrolled
Emanual Maverakis, MDPrincipal InvestigatorUC Davis
5 Previous Clinical Trials
58 Total Patients Enrolled

Media Library

Desonide 0.05% (Topical Steroid) Clinical Trial Eligibility Overview. Trial Name: NCT03437005 — Phase 1
Healthy Subjects Research Study Groups: Desonide 0.05%, Ketoconazole 2%
Healthy Subjects Clinical Trial 2023: Desonide 0.05% Highlights & Side Effects. Trial Name: NCT03437005 — Phase 1
Desonide 0.05% (Topical Steroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03437005 — Phase 1
Healthy Subjects Patient Testimony for trial: Trial Name: NCT03437005 — Phase 1
~3 spots leftby Sep 2026
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