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Broccoli Sprouts for Healthy Eating

N/A
Waitlist Available
Led By Emily Ho, PhD
Research Sponsored by Oregon State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy men and women, 18-60 years of age
Be between 18 and 65 years old
Must not have
Tobacco use, including e-cigarettes, or smoking of any substance (e.g. cannabis) in the past three months
Use of oral antibiotic medication within the 6 months
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 3, 6, 24, 48 and 72 hours after consuming a single serving of sprouts

Summary

This trial will study the effects of broccoli sprouts on the human body at a molecular and metabolic level. It will also look at the composition of the microbiome (the microorganisms that live in the gut).

Who is the study for?
This trial is for healthy men and women aged 18-60 who don't smoke or use tobacco, aren't pregnant, and haven't used antibiotics in the past 6 months. Participants must avoid certain foods and supplements before and during the study, have a BMI between 18.5 to 30, not exercise vigorously over 7 hours weekly, and be free of significant health issues.
What is being tested?
The study investigates how eating broccoli sprouts affects molecular profiles in blood, urine, and gut bacteria composition. It involves consuming either regular or specially labelled alfalfa or broccoli sprouts to track changes.
What are the potential side effects?
Since this trial involves eating common vegetables (broccoli & alfalfa sprouts), side effects are expected to be minimal but could include digestive discomfort due to dietary changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 60 years old and in good health.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have not used tobacco or smoked anything, including e-cigarettes and cannabis, in the last three months.
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I have not taken oral antibiotics in the last 6 months.
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I have a serious health condition like heart, kidney, liver disease, diabetes, thyroid issues, or had cancer treatment in the last 5 years.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 3, 6, 24, 48 and 72 hours after consuming a single serving of sprouts
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3, 6, 24, 48 and 72 hours after consuming a single serving of sprouts for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Plasma sulforaphane
Plasma sulforaphane metabolites
Stool sample based gut microbiome composition using 16S rRNA gene sequencing
+2 more

Trial Design

4Treatment groups
Active Control
Placebo Group
Group I: Broccoli sproutsActive Control1 Intervention
Subjects will consume one serving (about 1 cup) of broccoli sprouts with breakfast (bagel, cream cheese, and orange juice).
Group II: Deuterium oxide-labeled broccoli sproutsActive Control1 Intervention
Subjects will consume one serving (about 1 cup) of deuterium oxide-labeled broccoli sprouts with breakfast (bagel, cream cheese, and orange juice).
Group III: Deuterium oxide-labeled alfalfa sproutsPlacebo Group1 Intervention
Subjects will consume one serving (about 1 cup) of deuterium oxide-labeled alfalfa sprouts with breakfast (bagel, cream cheese, and orange juice).
Group IV: Alfalfa sproutsPlacebo Group1 Intervention
Subjects will consume one serving (about 1 cup) of alfalfa sprouts with breakfast (bagel, cream cheese, and orange juice).

Find a Location

Who is running the clinical trial?

Oregon State UniversityLead Sponsor
50 Previous Clinical Trials
8,351 Total Patients Enrolled
United States Department of Agriculture (USDA)FED
100 Previous Clinical Trials
286,596 Total Patients Enrolled
Emily Ho, PhDPrincipal InvestigatorOregon State University

Media Library

Alfalfa sprouts (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04641026 — N/A
Healthy Eating Research Study Groups: Broccoli sprouts, Deuterium oxide-labeled broccoli sprouts, Deuterium oxide-labeled alfalfa sprouts, Alfalfa sprouts
Healthy Eating Clinical Trial 2023: Alfalfa sprouts Highlights & Side Effects. Trial Name: NCT04641026 — N/A
Alfalfa sprouts (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04641026 — N/A
~10 spots leftby Jun 2025
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