ADHD Medications for Attention Deficit Hyperactivity Disorder (ADHD)
(BAT Trial)

Recruiting in Palo Alto (17 mi)

Overseen byAnne B Arnett, PhD

Age: < 18

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: Boston Children's Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial uses brain activity measurements to understand how children with ADHD will respond to two common medications. It focuses on children aged 7-11 who have not taken these medications before. By comparing brain activity at different times, researchers aim to find patterns that indicate which medication works best for each child. Methylphenidate is a widely used stimulant for treating ADHD, with studies exploring its benefits.

Research Team

Eugenia Chan, MD

Principal Investigator

Boston Children's Hospital

Anne B Arnett, PhD

Principal Investigator

Boston Children's Hospital

Eligibility Criteria

This trial is for children aged 7-11 with ADHD who haven't tried stimulant medications yet. They must be patients at the Children's Hospital Primary Care Center. Kids can't join if they have certain medical conditions like heart issues, intellectual disability, autism, a history of seizures or suicide attempts, are on other psychotropic meds, were born very premature or had prenatal substance exposure.

Inclusion Criteria

Have a diagnosis of ADHD or referred for an ADHD evaluation

I am a child aged 7-11 and am seen at the Children's Hospital Primary Care.

I have never taken stimulant medication before.

Exclusion Criteria

I have an intellectual disability, autism, or a known genetic syndrome.

I don't have heart issues that prevent me from using stimulant medications.

Prenatal alcohol or substance exposure

See 2 more

Treatment Details

Interventions

Adderall-XR (Central Nervous System Stimulant)
Concerta (Central Nervous System Stimulant)

Trial OverviewThe study tests how well kids with ADHD respond to two common meds: Concerta and Adderall-XR. It uses EEG to find brain activity patterns that might predict which med works better for them. First tested with Concerta for 3 weeks; if no improvement, then tested with Adderall-XR for another 3 weeks while monitoring symptoms and side effects.

Participant Groups

2Treatment groups

Active Control

Group I: Mixed Amphetamine Salts TrialActive Control1 Intervention

3-week trial of mixed amphetamine salts with weekly dose adjustments.

Group II: Methylphenidate TrialActive Control1 Intervention

3-week methylphenidate trial with weekly dose adjustments.