← Back to Search

NMDA receptor modulator

Drug: NRX-1074 375 mg for Depression (NRX-1074 Trial)

Phase 1
Waitlist Available
Led By Mimi Van Der Leden, MD, PhD
Research Sponsored by Naurex, Inc, an affiliate of Allergan plc
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up for 24 hours after drug dose on day 1
Awards & highlights

NRX-1074 Trial Summary

The purpose of this study is to assess the safety and tolerability of multiple oral (PO) ascending doses of NRX-1074 in normal healthy volunteers.

Eligible Conditions
  • Depression

NRX-1074 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~for 24 hours after drug dose on day 7
This trial's timeline: 3 weeks for screening, Varies for treatment, and for 24 hours after drug dose on day 7 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of participants with adverse events as a measure of safety and tolerability
Secondary outcome measures
Plasma pharmacokinetics - Tmax
Plasma pharmacokinetics Cmax

NRX-1074 Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Drug: NRX-1074 750 mgExperimental Treatment1 Intervention
Single oral administration on Day 1
Group II: Drug: NRX-1074 500 mgExperimental Treatment1 Intervention
Single oral administration on Day 1
Group III: Drug: NRX-1074 375 mgExperimental Treatment1 Intervention
Single oral administration on Day 1
Group IV: Drug: PlaceboPlacebo Group1 Intervention
Single oral administration on Day 1
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
NRX-1074
Not yet FDA approved
NRX-1074
Not yet FDA approved
NRX-1074
Not yet FDA approved

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Naurex, Inc, an affiliate of Allergan plcLead Sponsor
22 Previous Clinical Trials
6,069 Total Patients Enrolled
16 Trials studying Depression
5,615 Patients Enrolled for Depression
Mimi Van Der Leden, MD, PhDPrincipal InvestigatorChicago Research Center, Inc.
~1 spots leftby Jun 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top