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Aerobic Exercise for Epilepsy

Phase 1
Recruiting
Led By Jonathan J Russin, MD
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Candidacy for standard or selective temporal lobectomy
Age of 18 years or older
Must not have
Physical disabilities or medical conditions preventing participation in exercise program
Age older than 65 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 6 months
Awards & highlights
No Placebo-Only Group

Summary

This trial will test whether a six-month aerobic exercise regimen can improve cognition in 100 epilepsy patients.

Who is the study for?
This trial is for adults aged 18-65 with medically resistant mesial temporal lobe epilepsy who may undergo a lobectomy. It's not for those over 65, pregnant women, individuals unable to exercise due to physical or medical reasons, or those with cognitive disabilities that prevent participation in an exercise program.
What is being tested?
The study tests the effects of high and low-impact aerobic exercises on brain regeneration and cognitive improvement in epilepsy patients. The goal is to see if exercising can stimulate neurogenesis (growth of new neurons) which might help improve memory and cognition.
What are the potential side effects?
While specific side effects are not listed, typical risks associated with aerobic exercise may include muscle soreness, fatigue, joint stress, or injury. Participants should be monitored for any adverse reactions related to their condition.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am a candidate for surgery on the temporal lobe of my brain.
Select...
I am 18 years old or older.
Select...
I have been diagnosed with hard-to-treat epilepsy in the inner part of my temporal lobe.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a condition or disability that stops me from exercising.
Select...
I am older than 65 years.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Adherence to exercise and assessments
Secondary study objectives
Neurogenesis
Rey Auditory Verbal Learning Test (RAVLT) - Summary score
Rey Auditory Verbal Learning Test (RAVLT) - Trial V
+2 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: High-impact ExerciseExperimental Treatment1 Intervention
Group II: Low-impact ExerciseActive Control1 Intervention

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor
946 Previous Clinical Trials
1,604,609 Total Patients Enrolled
Jonathan J Russin, MDPrincipal InvestigatorUniversity of Southern California

Media Library

High-Impact Aerobic Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05179083 — Phase 1
Temporal Lobe Epilepsy Research Study Groups: High-impact Exercise, Low-impact Exercise
Temporal Lobe Epilepsy Clinical Trial 2023: High-Impact Aerobic Exercise Highlights & Side Effects. Trial Name: NCT05179083 — Phase 1
High-Impact Aerobic Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05179083 — Phase 1
~3 spots leftby Dec 2025
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