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Voriconazole and Quinidine with Repotrectinib for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Bristol-Myers Squibb
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Must not have
Gilbert's syndrome
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

This trial aims to see how taking voriconazole or quinidine with repotrectinib affects how the drug moves through the body in healthy men and women who cannot get pregnant.

Who is the study for?
This trial is for healthy adult men and women who cannot become pregnant. Participants must not have any significant health issues that could interfere with the study or be taking medications that might interact with the drugs being tested.
What is being tested?
The study is testing how repotrectinib, a medication, behaves in the body when taken with either voriconazole or quinidine. It's to see if these other drugs change how much repotrectinib gets into the bloodstream and how long it stays there.
What are the potential side effects?
Possible side effects of repotrectinib may include dizziness, fatigue, constipation, while voriconazole can cause visual changes and skin reactions. Quinidine might lead to nausea or heart-related issues.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have Gilbert's syndrome.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

2Treatment groups
Experimental Treatment
Group I: Part 2Experimental Treatment2 Interventions
Group II: Part 1Experimental Treatment2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Quinidine
2012
Completed Phase 1
~610
Voriconazole
2008
Completed Phase 4
~5740

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Bristol-Myers SquibbLead Sponsor
2,678 Previous Clinical Trials
4,125,613 Total Patients Enrolled
~21 spots leftby Dec 2024
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