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Oral Psilocybin for Healthy Subjects

Phase 1

Waitlist Available

Led By Christopher Nicholas, PhD

Research Sponsored by University of Wisconsin, Madison

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 8, day 22

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing psilocybin, taken as a pill or through an IV, in healthy adults. The study aims to see how the body absorbs it and its effects. Psilocybin turns into psilocin in the body, which causes the psychedelic experience. Psilocybin is a naturally occurring tryptamine known for its psychedelic properties and has been studied for its potential to treat depression and anxiety.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 8, day 22

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 8, day 22

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 8, day 22 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Determine the concentration of psilocin following oral and IV administrations of psilocybin

Determine the maximum concentration of psilocin following oral and IV administrations of psilocybin

Difference in the area under plasma concentration-time curve (AUC) between psilocybin administration methods.

+2 more

Secondary study objectives

Characterize the incidence and severity of adverse events associated with doses of psilocybin in healthy adults

Suicidal ideation

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Oral and IV psilocybinExperimental Treatment2 Interventions

Psilocybin with psychological support: Psilocybin will be administered in the form of capsules, taken orally with water, at one visit. Psilocybin will be administered through IV at the other visit.

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