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LY3871801 + Methotrexate (Part 1) for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up predose up to 96 hours postdose
Awards & highlights
No Placebo-Only Group

Summary

This trial tests how a new oral drug, LY3871801, affects the levels of other medications in healthy people. It checks for any side effects and how well people tolerate LY3871801 over several weeks.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~predose up to 96 hours postdose
This trial's timeline: 3 weeks for screening, Varies for treatment, and predose up to 96 hours postdose for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Methotrexate
Methotrexate
Dextromethorphan
+7 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: LY3871801 + Repaglinide + Drug Cocktail (Part 2)Experimental Treatment5 Interventions
LY3871801 administered orally in combination with repaglinide given orally and drug cocktail which includes warfarin, dextromethorphan and midazolam administered orally.
Group II: LY3871801 + Methotrexate (Part 1)Experimental Treatment2 Interventions
LY3871801 administered orally in combination with methotrexate given orally.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Warfarin
2017
Completed Phase 4
~248220
Repaglinide
2016
Completed Phase 4
~7010
LY3871801
2022
Completed Phase 1
~90
Midazolam
2018
Completed Phase 4
~1910
Methotrexate
2019
Completed Phase 4
~4400
Dextromethorphan
2019
Completed Phase 4
~920

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,657 Previous Clinical Trials
3,224,851 Total Patients Enrolled
Study DirectorEli Lilly and Company
1,380 Previous Clinical Trials
423,705 Total Patients Enrolled
~13 spots leftby Oct 2025
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