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RNA Vaccine

PF-07836395 Influenza saRNA for Flu

Phase 1
Waitlist Available
Research Sponsored by Pfizer
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 1-, 2-, and 4-weeks after vaccination

Summary

This trial is testing a new type of flu vaccine called the saRNA vaccine. It aims to see if the vaccine is safe and effective in healthy adults aged 18 to 49. The vaccine works by teaching the body to recognize and fight the flu virus. Participants will receive one shot and be monitored for several months.

Eligible Conditions
  • Flu
  • Flu-Related Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 1-, 2-, and 4-weeks after vaccination
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 1-, 2-, and 4-weeks after vaccination for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Percentage of participants reporting adverse events
Percentage of participants reporting local reactions
Percentage of participants reporting serious adverse events
+5 more
Secondary study objectives
Geometric mean fold rise (GMFR) in HAI titers from before vaccination to each subsequent timepoint
Geometric mean titers (GMTs) of hemagglutination inhibition (HAI) titers
Proportion of participants achieving HAI seroconversion for each strain
+1 more

Trial Design

26Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: PF-07915048 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group II: PF-07914705 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group III: PF-07914705 Influenza saRNA mid doseExperimental Treatment1 Intervention
Group IV: PF-07871987 Influenza saRNA, mid doseExperimental Treatment1 Intervention
Group V: PF-07871987 Influenza saRNA, low doseExperimental Treatment1 Intervention
Group VI: PF-07871987 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group VII: PF-07867246 Influenza saRNA, mid doseExperimental Treatment1 Intervention
Group VIII: PF-07867246 Influenza saRNA, low doseExperimental Treatment1 Intervention
Group IX: PF-07867246 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group X: PF-07852352 Influenza saRNA, mid doseExperimental Treatment1 Intervention
Group XI: PF-07852352 Influenza saRNA, low doseExperimental Treatment1 Intervention
Group XII: PF-07852352 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group XIII: PF-07836396 Influenza saRNA, mid doseExperimental Treatment1 Intervention
Group XIV: PF-07836396 Influenza saRNA, low doseExperimental Treatment1 Intervention
Group XV: PF-07836396 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group XVI: PF-07836395 Influenza saRNA, mid doseExperimental Treatment1 Intervention
Group XVII: PF-07836395 Influenza saRNA, low doseExperimental Treatment1 Intervention
Group XVIII: PF-07836395 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group XIX: PF-07836394 Influenza saRNA, mid doseExperimental Treatment1 Intervention
Group XX: PF-07836394 Influenza saRNA, low doseExperimental Treatment1 Intervention
Group XXI: PF-07836394 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group XXII: PF-07836391 Influenza saRNA, mid doseExperimental Treatment1 Intervention
Group XXIII: PF-07836391 Influenza saRNA, low doseExperimental Treatment1 Intervention
Group XXIV: PF-07836391 Influenza saRNA, high doseExperimental Treatment1 Intervention
Group XXV: Quadrivalent influenza vaccine (QIV)Active Control1 Intervention
Group XXVI: PlaceboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PF-07867246 Influenza saRNA
2022
Completed Phase 1
~450
PF-07914705 Influenza saRNA
2022
Completed Phase 1
~450
PF-07871987 Influenza saRNA
2022
Completed Phase 1
~450
PF-07915048 Influenza saRNA
2022
Completed Phase 1
~450
PF-07852352 Influenza saRNA 1
2022
Completed Phase 1
~450
PF-07836394 Influenza saRNA
2022
Completed Phase 1
~450
PF-07836396 Influenza saRNA
2022
Completed Phase 1
~450
PF-07836391 Influenza saRNA
2022
Completed Phase 1
~450
PF-07836395 Influenza saRNA
2022
Completed Phase 1
~450

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

PfizerLead Sponsor
4,661 Previous Clinical Trials
17,844,547 Total Patients Enrolled
Pfizer CT.gov Call CenterStudy DirectorPfizer
3,546 Previous Clinical Trials
14,885,703 Total Patients Enrolled
~123 spots leftby Dec 2025
Unbiased ResultsWe believe in providing patients with all the options.
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