L-Citrulline for Endothelial Function in Aging

Overseen by Andriy Yabluchanskiy, MD, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Recruiting

Sponsor: University of Oklahoma

No Placebo Group

Approved in 2 Jurisdictions

Trial Summary

What is the purpose of this trial?

This trial is studying the effects of L-Citrulline on brain blood vessel function. L-Citrulline is a supplement that can help improve blood flow by increasing nitric oxide levels in the body. The study focuses on older and less active people who often have lower nitric oxide levels. L-Citrulline has been shown to increase nitric oxide production, which can improve blood flow and has been studied for its effects on exercise performance and cardiovascular health.

Research Team

Andriy Yabluchanskiy, MD, PhD

Principal Investigator

University of Oklahoma

Eligibility Criteria

This trial is for adults aged 21-45 or 55-90 with good hearing and vision, who can read/write in English, and give informed consent. It's not for those with active brain diseases, recent strokes, major uncontrolled psychiatric conditions, substance abuse issues, or those on similar treatments recently.

Inclusion Criteria

I am between 21-45 or 55-90 years old.

I can see and hear well enough to take part in exams.

Ability to read and write in English

Exclusion Criteria

I do not have active brain disorders like MS, uncontrolled seizures, or brain cancer.

Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse

Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Treatment Details

Interventions

• L-Citrulline (Amino Acid)

Trial Overview The study tests the effects of a capsule containing L-Citrulline (2500 mg) on brain blood vessel function in healthy individuals as well as those experiencing aging-related changes.

Participant Groups

Group I: L-Citrulline Experimental Treatment 1 Intervention

L-Citrulline 50 g/day per os for 1 week

Who Is Running the Clinical Trial?

University of Oklahoma

Lead Sponsor

Trials

484

Recruited

95,900+