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CAR T-cell Therapy

AMV564 for Acute Myeloid Leukemia

Phase 1
Waitlist Available
Research Sponsored by Amphivena Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 42 months
Awards & highlights
No Placebo-Only Group
All Individual Drugs Already Approved

Summary

This trial is testing a new drug to see if it is safe and works well.

Eligible Conditions
  • Acute Myeloid Leukemia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~42 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 42 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Dose escalation + expansion stage: incidence of all adverse events and serious adverse events (safety and tolerability)
Expansion stage: Efficacy - Remission Rate

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Combination AMV564Experimental Treatment1 Intervention
Continuous infusion or subcutaneous dosing of AMV564 at increasing dose levels in combination with pembrolizumab
Group II: AMV564Experimental Treatment1 Intervention
Continuous infusion or subcutaneous dosing of AMV564 at increasing dose levels
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pembrolizumab
FDA approved
AMV564
2017
Completed Phase 1
~60

Find a Location

Who is running the clinical trial?

Amphivena Therapeutics, Inc.Lead Sponsor
2 Previous Clinical Trials
79 Total Patients Enrolled
Patrick Chun, MDStudy DirectorAmphivena Therapeutics, Inc.
2 Previous Clinical Trials
79 Total Patients Enrolled
~6 spots leftby Nov 2025
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