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Monoclonal Antibodies

Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma

Phase 1
Waitlist Available
Research Sponsored by TG Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 12 months
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a new treatment for people whose B-cell Non-Hodgkin's Lymphoma has come back or didn't respond to previous treatments. The treatment uses a drug called cosibelimab alone or combined with two other drugs, ublituximab and bendamustin. These drugs help the immune system fight cancer and directly attack cancer cells.

Eligible Conditions
  • Richter's Transformation
  • Non-Hodgkin's Lymphoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Adverse Events That Are Related to Treatment
Secondary study objectives
Overall Response Rate

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: Cohort CExperimental Treatment1 Intervention
Cosibelimab + Ublituximab + Bendamustine combination
Group II: Cohort BExperimental Treatment1 Intervention
Cosibelimab + Ublituximab + Bendamustine combination
Group III: Cohort AExperimental Treatment1 Intervention
Cosibelimab (TG-1501) single-agent

Find a Location

Who is running the clinical trial?

TG Therapeutics, Inc.Lead Sponsor
39 Previous Clinical Trials
6,840 Total Patients Enrolled
~3 spots leftby Dec 2025
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