Dronabinol Effects Related to Cannabis Use (THC-Gender-I Trial)

Phase 1

Recruiting

Research Sponsored by Yale University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Must not have

Taking estrogen supplements or oral contraceptive pills (for women)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and +80 minutes after start of oral dronabinol administration.

Summary

This trial will help researchers understand how cannabinoids affect men and women differently and what underlying mechanisms may cause these differences.

Who is the study for?

This trial is for healthy men and women who have tried cannabis at least once. Women must not be taking estrogen supplements or oral contraceptives, and participants with a sesame oil allergy cannot join. Those under major stress recently or currently are also excluded.

What is being tested?

The study aims to understand how cannabinoids affect men and women differently by comparing the effects of Dronabinol (a synthetic form of THC) to a placebo in healthy individuals.

What are the potential side effects?

Dronabinol can cause dizziness, dry mouth, feeling 'high', sleepiness, nausea, and sometimes confusion or hallucinations. The placebo should not cause any side effects unless there's an unexpected reaction.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am currently taking estrogen supplements or oral contraceptive pills.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and +80 minutes after start of oral dronabinol administration.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and +80 minutes after start of oral dronabinol administration.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and +80 minutes after start of oral dronabinol administration. for reporting.