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Acetylcholinesterase Inhibitor

Aricept to Improve Functional Tasks in Vascular Dementia

Phase 1
Waitlist Available
Led By A. M. Barrett, MD
Research Sponsored by Kessler Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
No Placebo-Only Group

Summary

This trial will test whether Aricept can help people with memory problems to better remember how to do everyday tasks.

Eligible Conditions
  • Memory Loss
  • Vascular Dementia
  • Stroke

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Aricept- AExperimental Treatment2 Interventions
Half of subjects are randomized to immediate treatment with donepezil 5mg orally daily following baseline testing, with retesting at 12 and 24 weeks.
Group II: A2-12-week waiting periodExperimental Treatment2 Interventions
The remaining nine subjects are randomized to testing followed by a 12-week waiting period. After the 12 week wait, this group of subjects is retested and begins taking donepezil, 5 mg orally daily, with retesting at 24 weeks

Find a Location

Who is running the clinical trial?

Kessler FoundationLead Sponsor
184 Previous Clinical Trials
11,251 Total Patients Enrolled
PfizerIndustry Sponsor
4,674 Previous Clinical Trials
17,827,142 Total Patients Enrolled
A. M. Barrett, MDPrincipal InvestigatorKessler Foundation
2 Previous Clinical Trials
1,110 Total Patients Enrolled
~1 spots leftby Dec 2025
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