Geniculate Artery Embolization for the Treatment of Knee Osteoarthritis

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: University of Calgary

No Placebo Group

Approved in 2 Jurisdictions

Trial Summary

What is the purpose of this trial?

Osteoarthritis (OA) is a highly prevalent degenerative joint disease that contributes to chronic pain and disability in approximately 10% of people over the age of 55. With 25% of Canadians expected to be aged 55 or older by 2036, an increasing number of Canadians will be impacted by knee OA. In affected individuals the risk of medical co-morbidities is increased which can lead to adverse cardiovascular outcomes, depression, and poorer quality of life. Current conservative therapy includes oral analgesia, lifestyle modification, corticosteroid injection, and viscosupplementation. These current conservative measures have variable responses. In patients who would prefer to avoid surgery or are not surgical candidates safe and consistently effective treatment options are lacking. Geniculate artery embolization (GAE) is a minimally invasive alternative with low risk of complications that has shown promise in exploratory studies. GAE provides benefit by disrupting angiogenesis in the knee which can contribute to chronic inflammation of the affected joint, and helps prevent the growth of new sensory nerve fibers which can reduce the pain associated with osteoarthritis.

Research Team

Eligibility Criteria

This trial is for individuals over 40 with knee osteoarthritis who haven't found relief from pain after at least 3 months of conservative treatments, such as medication or injections. It's aimed at those who are not candidates for surgery or choose not to undergo it.

Inclusion Criteria

I cannot or choose not to have surgery for my condition.

I am over 40 years old.

VAS score of at least 50 mm for knee pain

See 2 more

Exclusion Criteria

I have a local infection and inflammation in my joints.

Patient weight > 300 lbs

I need help with my daily activities due to my health condition.

See 7 more

Treatment Details

Interventions

Geniculate Artery Embolization (Procedure)

Trial OverviewThe trial is testing Geniculate Artery Embolization (GAE), a minimally invasive procedure designed to reduce inflammation and pain in the knee by disrupting blood vessel growth and nerve fiber development associated with osteoarthritis.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Geniculate Artery Embolization armExperimental Treatment1 Intervention