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Amino Acid

L-carnitine for Pulmonary Arterial Hypertension

Phase 1
Waitlist Available
Led By Anna R Hemnes
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 14 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial tests if carnitine supplements can help people with a type of high blood pressure affecting the lungs and heart by improving heart function. The study focuses on patients who often have heart issues due to fat buildup. By increasing carnitine levels, the treatment aims to help the heart use fats more effectively for energy. Carnitine has been shown to improve fat metabolism and has potential therapeutic benefits for cardiovascular disorders, including this type of high blood pressure.

Eligible Conditions
  • Pulmonary Arterial Hypertension
  • Lung Disease
  • Pulmonary Hypertension
  • Carnitine Deficiency

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~14 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 14 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Plasma Carnitine concentration
Secondary study objectives
Carnitine ingestion use through food
Echocardiography measurements of TAPSE and RV fractional area
Patient Reported Side Effects
+4 more

Side effects data

From 2021 Phase 2 & 3 trial • 144 Patients • NCT01783041
25%
Patent ductus arteriosus
19%
Bronchopulmonary Dysplasia
6%
Blood culture positive sepsis
4%
Intraventricular hemorrhage
100%
80%
60%
40%
20%
0%
Study treatment Arm
5% Dextrose
L-carnitine

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: SupplementExperimental Treatment1 Intervention
Form: 500 mg L-carnitine tablet Dosage: Subjects 50-90kg: 3g/day Subjects \<50kg or \>90kg: 50mg/kg/day Frequency: twice a day for 2 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
L-carnitine
2002
Completed Phase 4
~930

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
902 Previous Clinical Trials
938,822 Total Patients Enrolled
11 Trials studying Pulmonary Arterial Hypertension
2,526 Patients Enrolled for Pulmonary Arterial Hypertension
Anna R HemnesPrincipal InvestigatorVanderbilt University Medical Center
~2 spots leftby Nov 2025
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