THC for Cannabis Intoxication
(SAGE Trial)

Recruiting in Palo Alto (17 mi)

Overseen byZiva Cooper, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Recruiting

Sponsor: University of California, Los Angeles

Trial Summary

What is the purpose of this trial?This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.

Eligibility Criteria

This trial is for males and non-pregnant females aged 18-65 who use cannabis weekly to monthly, primarily by inhalation, over the last 6 months. They should not be seeking treatment for cannabis use, have no significant adverse effects from it, and must have a BMI of 18.5-34kg/m2. Women must use effective birth control if pre-menopausal.

Inclusion Criteria

Not currently seeking treatment for their cannabis use

I am using effective birth control and am pre-menopausal.

I am between 18-65 years old and fit into one of the specified age groups.

+4 more

Participant Groups

The study examines how smoked and oral THC affects people differently based on their age. It looks at potential abuse, intoxication levels, pain relief (analgesia), and impairment in adults grouped as emerging (18-25), middle-aged (35-45), and late middle-aged (55-65).

5Treatment groups

Experimental Treatment

Placebo Group

Group I: Experimental: Low strength oral THCExperimental Treatment2 Interventions

Smoked Cannabis (0 mg THC) Oral THC (10 mg THC)

Group II: Experimental: Low strength cannabisExperimental Treatment2 Interventions

Smoked Cannabis (10 mg THC) Oral placebo (0 mg THC)

Group III: Experimental: Higher strength oral THCExperimental Treatment2 Interventions

Smoked Cannabis (0 mg THC) Oral THC (20 mg THC)

Group IV: Experimental: Higher strength cannabisExperimental Treatment2 Interventions

Smoked Cannabis (20 mg THC) Oral placebo (0 mg THC)

Group V: Placebo Comparator: PlaceboPlacebo Group2 Interventions