Intermittent Fasting for Microalbuminuria
(TREK Trial)

Recruiting in Palo Alto (17 mi)

Overseen byPam Taub, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: University of California, San Diego

No Placebo Group

Trial Summary

What is the purpose of this trial?This is a clinical trial to assess how time-restricted eating (TRE) may improve kidney health and filtration patients with type 2 diabetes and increased protein content in their urine. All participants will be participating in TRE in which they follow a consistent 8-10 hour eating window everyday.

Eligibility Criteria

This trial is for individuals with type 2 diabetes who also have microalbuminuria, which means there's a bit more protein in their urine than normal. Participants should be willing to eat within an 8-10 hour window every day.

Inclusion Criteria

uACR (urine albumin creatinine ratio) results ≥ 30 - 300 mg

Willingness to use smartphone for research procedures (Apple iOS or Android OS)

Baseline eating period ≥12 hours/day and sufficient logging on the mCC app

+7 more

Exclusion Criteria

Shift workers with variable (e.g., nocturnal) hours

Estimated Glomerular Filtration Rate (EGFR) < 45

LDL cholesterol greater than 200 mg/dL

+25 more

Participant Groups

The study is testing whether time-restricted eating (TRE), where participants only eat during a set period of the day, can improve kidney function and reduce protein levels in urine for those with type 2 diabetes.

1Treatment groups

Experimental Treatment

Group I: Time Restricted Eating (TRE) GroupExperimental Treatment1 Intervention

Participants will limit the number of hours they eat in a dat to an 8-10 window and will also receive the standard heath and nutritional wellness guidelines. They will also be required to log food entries through the use of a smartphone app. Patients will also be required to wear a continuous glucose monitor (CGM) for the first and last two weeks of the 14 trial.