Healthy Lifestyle Intervention for Bone Health
(LIMB-Q Trial)

Recruiting in Palo Alto (17 mi)

Overseen ByDennis T Villareal, MD

Age: 65+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Baylor College of Medicine

No Placebo Group

Trial Summary

What is the purpose of this trial?Obese older adults will be randomized to participate in either healthy lifestyle intervention or behavioral diet and exercise intervention for one year. This study aims to determine the effects of Lifestyle intervention on bone microarchitecture, bone strength, bone material properties, and the mechanism behind it.

Eligibility Criteria

This trial is for obese older adults aged 65-85 with a BMI of 30-40 who are sedentary and have had a stable body weight in the last six months. It's not for those with osteoporosis, severe diseases that limit exercise, cognitive impairments, uncontrolled hypertension, recent cancer (except skin), or on certain medications.

Inclusion Criteria

Sedentary (regular exercise <1 h/wk. or <2 x/wk. for the last 6 months)

Stable body weight (±2 kg) during the past 6 months

BMI 30 - 40 kg/m2

+2 more

Exclusion Criteria

I do not have severe heart or lung conditions that would prevent me from exercising or dieting.

I have osteoporosis or have had fractures from minor injuries.

I do not have major health or psychiatric issues that would stop me from joining an exercise program.

+12 more

Participant Groups

The study compares two groups: one follows a healthy lifestyle intervention while the other engages in both diet and exercise changes for one year. The goal is to see how these interventions affect bone strength and quality in aging individuals.

2Treatment groups

Experimental Treatment

Active Control

Group I: Lifestyle intervention GroupExperimental Treatment1 Intervention

Behavioral therapy for weight loss and Exercise Training

Group II: Healthy lifestyle intervention GroupActive Control1 Intervention

Group education sessions that focus on diet exercise and social support.