What side effects are associated with this type of intervention?

Common treatments for Chronic Kidney Disease (CKD) include lifestyle modifications such as home-based exercise programs aimed at improving physical function and health-related quality of life. These exercise programs are generally safe but can have side effects such as muscle soreness, fatigue, and, in rare cases, injury if not performed correctly. It is important for patients to follow a structured and individualized exercise plan to minimize these risks. Additionally, other treatments for CKD, such as medications to control blood pressure and blood sugar, can have side effects including dizziness, gastrointestinal issues, and electrolyte imbalances.

What prior FDA approvals exist?

The FDA has approved several pharmacologic treatments for Chronic Kidney Disease (CKD), including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), and sodium-glucose co-transporter 2 (SGLT2) inhibitors, which help manage blood pressure and reduce proteinuria. However, non-pharmacologic interventions like home-based exercise, which aim to improve physical function and quality of life, are also being studied. While these exercise programs are not FDA-approved treatments, they are recognized as beneficial adjuncts to traditional medical therapies for CKD patients.

What other types of research exist?

Promising novel alternatives to home-based exercise for CKD patients include: 1) Nutritional interventions tailored to CKD patients, focusing on specific dietary modifications to improve kidney function and overall health. 2) Pharmacological agents targeting inflammation and oxidative stress, which are common in CKD and contribute to disease progression. 3) Telehealth and remote monitoring technologies to provide continuous care and personalized treatment plans. 4) Regenerative medicine approaches, such as stem cell therapy, to repair and regenerate damaged kidney tissues. 5) Gut microbiome modulation through probiotics or prebiotics to improve metabolic health and reduce uremic toxins.

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Home-Based Exercise for Chronic Kidney Disease

N/A

Waitlist Available

Led By Elizabeth C Lorenz, MD

Research Sponsored by Baylor College of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

No Placebo-Only Group

Summary

This trial tests if home-based exercise can improve physical function in frail or pre-frail kidney transplant candidates. Participants will use simple equipment at home to follow a personalized exercise plan. The goal is to enhance their strength, balance, and overall health.

Who is the study for?

This trial is for adults over 18 with any stage of chronic kidney disease who are frail or pre-frail, as measured by specific criteria. They must be able to consent to research and pass a submaximal exercise test if not approved for kidney transplantation. Those with severe heart, lung conditions, or needing multiple organ transplants cannot join.

What is being tested?

The study tests an 8-week home-based exercise program's effectiveness in improving physical function, frailty parameters, SPPB scores (a measure of balance and mobility), quality of life, activity levels, and reducing hospitalizations among kidney transplant candidates.

What are the potential side effects?

While the trial does not list specific side effects due to its nature focusing on exercise intervention rather than medication, participants may experience typical exercise-related discomforts such as muscle soreness or fatigue.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Short Physical Performance Battery score

Secondary study objectives

Change in exhaustion

Change in gait speed

Change in grip strength

+4 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: InterventionExperimental Treatment1 Intervention

Participants will be asked to complete an 8-week home-based exercise intervention

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Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for Chronic Kidney Disease (CKD) include lifestyle modifications like home-based exercise, which aims to improve physical function and quality of life. Exercise helps by enhancing cardiovascular health, reducing inflammation, and improving muscle strength, which are crucial for CKD patients who often suffer from decreased physical function and frailty. Additionally, controlling blood pressure through medications and lifestyle changes is essential to slow the progression of CKD and prevent complications. These treatments matter because they address both the symptoms and underlying causes of CKD, thereby improving patient outcomes and quality of life.

Uremic Sarcopenia: Clinical Evidence and Basic Experimental Approach.