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Radiation

Automated MR-Guided Radiation for Breast Cancer

N/A
Waitlist Available
Led By Robert Dinniwell, M.D.
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions
≥ 18 years of age
Must not have
< 18 years of age
Males
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is investigating the feasibility of using automated planning tools with a new MR-guided linac to do on-line adaptive radiation treatment for early stage breast cancer patients.

Who is the study for?
This trial is for female patients over 18 with any stage of breast cancer, who will undergo standard whole breast radiation therapy. It's open to those who've had surgery or chemotherapy for any cancer type and can consent in writing.
What is being tested?
The study tests an automated planning tool that uses MR images from a new MR-guided linac for on-line adaptive radiation treatment, aiming to refine this technology and validate its clinical use without extra ionizing radiation.
What are the potential side effects?
While the document doesn't specify side effects, typical ones from IMRT (radiation therapy) may include skin irritation, fatigue, swelling in the treated area, and changes in breast size or shape.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I will receive standard breast radiation therapy in one of the specified dose plans.
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I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am under 18 years old.
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I am male.
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I will not receive specific radiation doses mentioned.
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I received lower than the standard dose of radiation for my breast.
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I am unable to understand and give consent for my treatment.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: IMRT + CT + MR scanExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,531 Previous Clinical Trials
504,162 Total Patients Enrolled
54 Trials studying Breast Cancer
29,605 Patients Enrolled for Breast Cancer
Princess Margaret Hospital, CanadaOTHER
120 Previous Clinical Trials
39,792 Total Patients Enrolled
11 Trials studying Breast Cancer
22,687 Patients Enrolled for Breast Cancer
Robert Dinniwell, M.D.Principal InvestigatorPrincess Margaret Cancer Centre
Tom Purdie, PhysicistPrincipal InvestigatorPrincess Margaret Cancer Centre

Media Library

Breast Cancer Research Study Groups: IMRT + CT + MR scan
~13 spots leftby Dec 2025
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