← Back to Search

Other

Coronary Calcium Screening + Statins for Cardiovascular Prevention (CorCal Trial)

N/A

Recruiting

Led By Joseph B Muhlestein, MD

Research Sponsored by Intermountain Health Care, Inc.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

No known history, as documented in the EHR, of coronary artery disease, cerebrovascular disease, peripheral vascular disease, or diabetes mellitus at enrollment

Be older than 18 years old

Must not have

Any evidence of statin use prior to study participation

Patients who have active on-going cancer or are on dialysis

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

No Placebo-Only Group

Summary

This trial will test whether a proactive cardiovascular prevention strategy, with or without coronary calcium screening, can prevent major adverse cardiac events better than current standard care.

Who is the study for?

This trial is for men aged 50-80 and women aged 60-80 with no history of cardiovascular disease or diabetes, who haven't used statins or had a coronary calcium test in the last 5 years. Participants must be able to provide electronic health records and understand study procedures.

What is being tested?

The study tests if proactive heart disease prevention strategies, including coronary artery calcium screening followed by statin treatment, can prevent major cardiac events better than standard care in people at moderate risk but without current heart disease.

What are the potential side effects?

Potential side effects may include those commonly associated with statins such as muscle pain, fatigue, digestive problems, and increased blood sugar levels which could lead to diabetes. The CT scan for calcium screening carries minimal risks like radiation exposure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have no history of heart, brain blood vessel, peripheral artery diseases, or diabetes.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have taken statins before joining the study.

Select...

I am currently undergoing dialysis or have active cancer.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

MACE

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Proactive CAC GroupExperimental Treatment1 Intervention

Investigational Interventional Group. Will undergo coronary artery calcium screening and will receive statin recommendation based on the cardiovascular risk algorithm.

Group II: Proactive Current National Guidelines GroupActive Control1 Intervention

Standard Interventional Control Group. Will receive treatment recommendation according to the current National guidelines for statin initiation and follow-up.

0 / 3Eligibility criteria met