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Biologic Mesh

Biologic Meshes for Ventral Hernia

Phase 2 & 3
Recruiting
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult patients, 18 years or older, undergoing an abdominal wall reconstruction
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial will compare the two most popular types of biologic mesh to see which is better.

Who is the study for?
This trial is for adults over 18 who need abdominal wall reconstruction and have agreed that a biologic implant is necessary. Two surgeons involved in the trial must concur on this decision. Participants must be able to give informed consent; those who can't will not be eligible.
What is being tested?
The study compares two popular biologic mesh materials used in abdominal wall reconstructions: Strattice (noncross-linked porcine dermis) and Permacol (cross-linked porcine dermis). Patients are randomly assigned one of these meshes to evaluate their performance.
What are the potential side effects?
While specific side effects aren't listed, potential risks may include infection, rejection or failure of the mesh, allergic reactions, pain at the surgical site, and complications related to surgery.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am an adult scheduled for abdominal wall reconstruction.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Permacol biologic meshExperimental Treatment1 Intervention
Permacol mesh is made of cross-linked porcine dermis, which is used to support abdominal wall reconstruction.
Group II: Strattice biologic meshActive Control1 Intervention
Strattice mesh is made of noncross-linked porcine dermis, which is used to support abdominal wall reconstruction.

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
810 Previous Clinical Trials
886,204 Total Patients Enrolled
MedtronicIndustry Sponsor
619 Previous Clinical Trials
763,998 Total Patients Enrolled

Media Library

Permacol biologic mesh (Biologic Mesh) Clinical Trial Eligibility Overview. Trial Name: NCT02703662 — Phase 2 & 3
Ventral Hernia Research Study Groups: Strattice biologic mesh, Permacol biologic mesh
Ventral Hernia Clinical Trial 2023: Permacol biologic mesh Highlights & Side Effects. Trial Name: NCT02703662 — Phase 2 & 3
Permacol biologic mesh (Biologic Mesh) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02703662 — Phase 2 & 3
~9 spots leftby Oct 2025
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