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BEnefits of Stroke Treatment Delivered Using a Mobile Stroke Unit (BEST-MSU Trial)

Phase 2 & 3
Waitlist Available
Led By James C Grotta, MD
Research Sponsored by Memorial Hermann Health System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 year from date of enrollment
Awards & highlights
No Placebo-Only Group

Summary

This trial will compare pre-hospital diagnosis and treatment of patients with stroke symptoms using a Mobile Stroke Unit (MSU) with subsequent transfer to a Comprehensive Stroke Center (CSC) Emergency Department (ED), to standard pre-hospital triage and transport by Emergency Medical Services (EMS) to a CSC ED.

Eligible Conditions
  • Stroke

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 year from date of enrollment
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year from date of enrollment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Agreement between on scene Vascular Neurologist vs. Remote (Telemedicine) Vascular Neurologist
Cost Effectiveness (N.B. The BEST-MSU study including measurement of heatlhcare utilization is funded by PCORI. The cost-effectiveness measures are not covered by PCORI funding and will be reported separately)
Utility-weighted modified Rankin Scale (uw-mRS) from baseline to 90 days
Secondary study objectives
90 day Modified Rankin Score
Stroke mimics
Symptomatic intracranial hemorrhage and mortality
+2 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Mobile Stroke Unit ManagementActive Control1 Intervention
Acute ischemic stroke patients treated in the Mobile Stroke Unit
Group II: Standard ManagementActive Control1 Intervention
Acute ischemic stroke patients receiving standard management

Find a Location

Who is running the clinical trial?

City of Houston Fire DepartmentUNKNOWN
Ben Taub HospitalOTHER
2 Previous Clinical Trials
50 Total Patients Enrolled
West University Fire DepartmentUNKNOWN
Patient-Centered Outcomes Research InstituteOTHER
576 Previous Clinical Trials
27,078,649 Total Patients Enrolled
6 Trials studying Stroke
170,083 Patients Enrolled for Stroke
CHI St. Luke's Health, TexasOTHER
5 Previous Clinical Trials
497 Total Patients Enrolled
The University of Texas Health Science Center, HoustonOTHER
957 Previous Clinical Trials
347,018 Total Patients Enrolled
45 Trials studying Stroke
8,491 Patients Enrolled for Stroke
Baylor College of MedicineOTHER
1,025 Previous Clinical Trials
6,028,744 Total Patients Enrolled
4 Trials studying Stroke
190 Patients Enrolled for Stroke
City of Bellaire Fire DepartmentUNKNOWN
Harris HealthUNKNOWN
2 Previous Clinical Trials
415 Total Patients Enrolled
The Methodist Hospital Research InstituteOTHER
286 Previous Clinical Trials
80,728 Total Patients Enrolled
5 Trials studying Stroke
276 Patients Enrolled for Stroke
~92 spots leftby Dec 2025
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