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Opioid Analgesic

Remifentanil Hydrochloride for Respiratory Depression

Phase 2 & 3
Recruiting
Led By Rachel Eshima McKay, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, and every 2.5 minutes during 10-minute infusion and 25-minute recovery
Awards & highlights

Study Summary

This trial will study the effects of opioids on the pupils of people aged 40 to 60, to see if it is a good indicator of opioid toxicity and respiratory depression in this age group.

Eligible Conditions
  • Respiratory Depression
  • Constricted Pupils
  • Opioid Overdose

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, and every 2.5 minutes during 10-minute infusion and 25-minute recovery
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, and every 2.5 minutes during 10-minute infusion and 25-minute recovery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Area Under the Time Concentration Curve (AUC 0-35 minutes)

Trial Design

2Treatment groups
Experimental Treatment
Group I: Noninteractive, then InteractiveExperimental Treatment2 Interventions
Participants undergo the infusion under noninteractive conditions, followed by a second drug infusion under interactive conditions.
Group II: Interactive, then NoninteractiveExperimental Treatment2 Interventions
Participants undergo the infusion under interactive conditions, followed by a second drug infusion under noninteractive conditions.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Remifentanil
FDA approved

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,520 Previous Clinical Trials
15,241,925 Total Patients Enrolled
1 Trials studying Respiratory Depression
20 Patients Enrolled for Respiratory Depression
Rachel Eshima McKay, MDPrincipal InvestigatorProfessor of Anesthesia
~7 spots leftby Jun 2025
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