Olanzapine and Mirtazapine for Weight Loss in Advanced Stage Cancer
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: Englewood Hospital and Medical Center
No Placebo Group
Prior Safety Data
Trial Summary
What is the purpose of this trial?
This trial is testing two medications, olanzapine and mirtazapine, to see which one helps cancer patients keep their weight and appetite. Cancer patients often lose weight and appetite, and these drugs might help by making them feel better emotionally and physically. Olanzapine and mirtazapine have been shown to improve appetite and reduce nausea in cancer patients, which can help with weight maintenance.
Eligibility Criteria
This trial is for adults with advanced cancer who have lost more than 5% of their weight unintentionally over the last 3-6 months, despite nutritional support. They must be able to consent, communicate effectively, and have a life expectancy of at least 4 months. Those on dexamethasone or undergoing chemotherapy can join. People using Marinol recently, with abnormal heart rhythms or liver function, or primarily fed intravenously cannot participate.Inclusion Criteria
You have lost more than 5% of your body weight over the last 3-6 months without trying to lose weight. This is not due to just not eating, and has not improved with standard nutrition advice and supplements for at least 2 weeks.
18 years of age or older
Able to provide informed consent
See 6 more
Exclusion Criteria
You have taken Marinol within two weeks before joining the study.
Elevated QTc (EKG performed within 1 year of enrollment will be accepted)
Total parental nutrition (TPN) or enteral feeds (PEG/PEJ) for >70% of their primary source of daily calorie intake
See 1 more
Treatment Details
Interventions
- Mirtazapine (Antidepressant)
- Olanzapine (Antipsychotic)
Trial OverviewThe study aims to compare the effectiveness of two medications, Olanzapine and Mirtazapine, in preventing further weight loss and appetite loss in patients with advanced stage cancer. It will assess which drug better helps manage these symptoms associated with cancer.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: OlanzapineExperimental Treatment1 Intervention
Group II: MirtazapineExperimental Treatment1 Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Englewood Hospital and Medical Center
Lead Sponsor
Trials
21
Recruited
770+